Evidence map›Paper›PMID 36851491›Full record

ArticleViruses2023

Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia (Italy) during the First and Second COVID-19 Epidemic Waves.

Angela Maria Rocchigiani, Luca Ferretti, Alice Ledda, Antonello Di Nardo, Matteo Floris, Piero Bonelli, Federica Loi, Maria Laura Idda, Pier Paolo Angioi, Susanna Zinellu and 27 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 6 institutions in 2 countries.

Angela Maria RocchigianiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Luca FerrettiPandemic Sciences Institute and Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department for Medicine, University of Oxford, Oxford OX1 2JD, UK.ORCID 0000-0001-7578-7301
Alice LeddaUK Health Security Agency, Colindale, London NW9 5EQ, UK.
Antonello Di NardoThe Pirbright Institute, Ash Road, Pirbright, Woking GU24 0NF, UK.ORCID 0000-0003-0352-0039
Matteo FlorisDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-4385-9336
Piero BonelliIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0003-4462-8257
Federica LoiOsservatorio Epidemiologico Veterinario Regionale, Istituto Zooprofilattico Sperimentale della Sardegna, 09125 Cagliari, Italy.ORCID 0000-0003-3045-3150
Maria Laura IddaInstitute for Genetic and Biomedical Research (IRGB), National Research Council (CNR), 07100 Sassari, Italy.ORCID 0000-0001-5243-8977
Pier Paolo AngioiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Susanna ZinelluIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Mariangela Stefania FioriIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0002-1292-5022
Roberto BechereIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Paola CapittaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Annamaria CoccolloneIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Elisabetta CoradduzzaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0001-6942-3296
Maria Antonietta DettoriIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Maria Caterina FattaccioIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Elena GallisaiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Caterina MaestraleIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Daniela ManuntaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Aureliana PedditziIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Ivana PireddaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0002-2878-4682
Bruna PalmasIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Sara SalzaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0003-0289-0716
Anna Maria SechiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Barbara TandaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Maria Paola MadrauIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Maria Luisa SannaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Simonetta CherchiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Nicoletta PontiIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Giovanna MasalaIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Roberto SiricaAmes Polydiagnostic Group Center SRL, 80013 Napoli, Italy.
Eloisa EvangelistaAmes Polydiagnostic Group Center SRL, 80013 Napoli, Italy.
Annalisa OggianoIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0002-3167-0942
Giantonella PuggioniIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0001-9013-8203
Ciriaco LigiosIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Silvia Dei GiudiciIstituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.ORCID 0000-0003-1803-4666
Istituto Zooprofilattico Sperimentale della Sardegna · ITInstitute of Genetic and Biomedical Research · ITThe Pirbright Institute · GBUK Health Security Agency · GBUniversity of Oxford · GBUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding how geography and human mobility shape the patterns and spread of infectious diseases such as COVID-19 is key to control future epidemics. An interesting example is provided by the second wave of the COVID-19 epidemic in Europe, which was facilitated by the intense movement of tourists around the Mediterranean coast in summer 2020. The Italian island of Sardinia is a major tourist destination and is widely believed to be the origin of the second Italian wave. In this study, we characterize the genetic variation among SARS-CoV-2 strains circulating in northern Sardinia during the first and second Italian waves using both Illumina and Oxford Nanopore Technologies Next Generation Sequencing methods. Most viruses were placed into a single clade, implying that despite substantial virus inflow, most outbreaks did not spread widely. The second epidemic wave on the island was actually driven by local transmission of a single B.1.177 subclade. Phylogeographic analyses further suggest that those viral strains circulating on the island were not a relevant source for the second epidemic wave in Italy. This result, however, does not rule out the possibility of intense mixing and transmission of the virus among tourists as a major contributor to the second Italian wave.

Indexed as

COVID-19SARS-CoV-2Genetic VariationHumansItalyMolecular EpidemiologyPhylogeographygenetic diversitymolecular epidemiologySARS-CoV-2spike (S) proteinwhole genome sequencing

Identifiers

PMID36851491
PMCPMC9961045
OpenAlexW4317423779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.