Evidence map›Paper›PMID 36851451›Full record

ArticleVeterinary sciences2023

KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers.

Heike Aupperle-Lellbach, Daniela Heidrich, Alexandra Kehl, David Conrad, Maria Brockmann, Katrin Törner, Christoph Beitzinger, Tobias Müller

Open access · goldAbstract read
In one paragraph

Article in Veterinary sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Heike Aupperle-LellbachLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.
Daniela HeidrichLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.
Alexandra KehlLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.ORCID 0000-0002-1547-0713
David ConradLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.
Maria BrockmannLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.ORCID 0000-0002-6162-7515
Katrin TörnerLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.
Christoph BeitzingerLABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.
Tobias MüllerInstitut für Bioinformatik, Universität Würzburg, 97070 Würzburg, Germany.ORCID 0000-0003-3035-7070
Laboklin (Germany) · DEUniversity of Würzburg · DE

Funding

Bavarian Research Foundation AZ-1365-18
6 · The paper itself

Abstract

Copy number variations (CNVs) of the KITLG gene seem to be involved in the oncogenesis of digital squamous cell carcinoma (dSCC). The aims of this study were (1) to investigate KITLG CNV in giant (GS), standard (SS), and miniature (MS) schnauzers and (2) to compare KITLG CNV between black GS with and without dSCC. Blood samples from black GS (22 with and 17 without dSCC), black SS (18 with and 4 without dSSC; 5 unknown), and 50 MS (unknown dSSC status and coat colour) were analysed by digital droplet PCR. The results are that (1) most dogs had a copy number (CN) value > 4 (range 2.5-7.6) with no significant differences between GS, SS, and MS, and (2) the CN value in black GS with dSCC was significantly higher than in those without dSCC (

Indexed as

breed predispositionCNVddPCRminiature schnauzerstandard schnauzertoetumour

Identifiers

PMID36851451
PMCPMC9966798
OpenAlexW4320495984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.