Evidence map›Paper›PMID 36851352›Full record

ArticleVaccines2023

Development of Autoantibodies Following BNT162b2 mRNA COVID-19 Vaccination and Their Association with Disease Flares in Adult Patients with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) and the General Population: Results of 1-Year Prospective Follow-Up Study.

Tal Gazitt, Tali Eviatar, Jacqueline Shear, Roni Meidan, Victoria Furer, Joy Feld, Amir Haddad, Muna Elias, Nizar Hijazi, Nili Stein and 5 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Tal GazittCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.ORCID 0000-0001-8612-2698
Tali EviatarTel Aviv Medical Center, Rheumatology, Tel Aviv 6423906, Israel.
Jacqueline ShearThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.
Roni MeidanTel Aviv Medical Center, Rheumatology, Tel Aviv 6423906, Israel.
Victoria FurerTel Aviv Medical Center, Rheumatology, Tel Aviv 6423906, Israel.ORCID 0000-0001-5193-4207
Joy FeldCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Amir HaddadCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Muna EliasCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Nizar HijaziCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Nili SteinDepartment of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 3436212, Israel.
Pninit Shaked MishanMicrobiology and Immunology Laboratory, Carmel Medical Center, Haifa 3436212, Israel.
Anna ZetserMicrobiology and Immunology Laboratory, Carmel Medical Center, Haifa 3436212, Israel.
Hagit PelegRheumatology Unit, Hadassah Medical Center, Jerusalem 91120, Israel.
Ori ElkayamTel Aviv Medical Center, Rheumatology, Tel Aviv 6423906, Israel.
Devy ZismanCarmel Medical Center, Rheumatology Unit, Haifa 3436212, Israel.
Carmel Medical Center · ILTel Aviv University · ILHadassah Medical Center · ILUniversity of Washington Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of autoantibodies following BNT162b2 mRNA COVID-19 vaccination and their association with disease flares in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) and the general population: results of 1-year prospective follow-up study. We conducted a prospective study aimed at investigating the incidence of appearance of autoantibodies (antinuclear, antiphospholipid, and rheumatoid factor) in the sera of 463 adult patients with AIIRD compared to 55 controls from the general population prior to, and following the second and third vaccine doses, and at 1-year of follow-up. Pre- and post-vaccination disease activity indices and the association of autoantibodies with rheumatic disease flares and new onset AIIRD were examined. Autoantibody development of any type in AIIRD patients vs. the controls was 4.0% (vs. 6.7%,

Indexed as

autoantibodiesCOVID-19disease flaresmRNA vaccineSARS-CoV-2

Identifiers

PMID36851352
PMCPMC9958930
OpenAlexW4321372754

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.