Evidence map›Paper›PMID 36851339›Full record

ArticleVaccines2023

Oral and Subcutaneous Immunization with a Plant-Produced Mouse-Specific Zona Pellucida 3 Peptide Presented on Hepatitis B Core Antigen Virus-like Particles.

Khadijeh Ghasemian, Inge Broer, Jennifer Schön, Richard Killisch, Nadine Kolp, Armin Springer, Jana Huckauf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Khadijeh GhasemianDepartment of Agrobiotechnology and Risk Assessment for Bio and Gene Technology, Faculty of Agricultural and Environmental Sciences, University of Rostock, 18059 Rostock, Germany.
Inge BroerDepartment of Agrobiotechnology and Risk Assessment for Bio and Gene Technology, Faculty of Agricultural and Environmental Sciences, University of Rostock, 18059 Rostock, Germany.
Jennifer SchönDepartment of Reproduction Biology, Leibniz Institute for Zoo and Wildlife Research (IZW), 10315 Berlin, Germany.
Richard KillischBIOSERV, Analytik und Medizinprodukte GmbH, 18059 Rostock, Germany.
Nadine KolpBIOSERV, Analytik und Medizinprodukte GmbH, 18059 Rostock, Germany.
Armin SpringerMedical Biology and Electron Microscopy Center, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0001-9878-7240
Jana HuckaufDepartment of Agrobiotechnology and Risk Assessment for Bio and Gene Technology, Faculty of Agricultural and Environmental Sciences, University of Rostock, 18059 Rostock, Germany.
University of Rostock · DELeibniz Institute for Zoo and Wildlife Research · DE

Funding

University of Rostock Landesgraduiertenförderung Mecklenburg-Vorpommern
6 · The paper itself

Abstract

A short mouse-specific peptide from zona pellucida 3 (mZP3, amino acids 328-342) has been shown to be associated with antibody-mediated contraception. In this study, we investigated the production of mZP3 in the plant, as an orally applicable host, and examined the immunogenicity of this small peptide in the BALB/c mouse model. The mZP3 peptide was inserted into the major immunodominant region of the hepatitis B core antigen and was produced in

Indexed as

chimeric virus-like particlescontraceptive vaccineNicotiana benthamianaoral vaccineplant molecular farmingzona pellucida 3 peptide

Identifiers

PMID36851339
PMCPMC9963689
OpenAlexW4321252229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.