ArticleVaccines2023
Immunogenicity and Safety of a Combined Intramuscular/Intranasal Recombinant Spike Protein COVID-19 Vaccine (RCP) in Healthy Adults Aged 18 to 55 Years Old: A Randomized, Double-Blind, Placebo-Controlled, Phase I Trial.
Open access · goldAbstract read
In one paragraph
Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026Pooled it
- Trial
- Current status of intranasal and inhaled COVID-19 vaccines.NPJ vaccines · 2026Review
- Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025Review
- Review
- Self-assembling TLR2 agonists promote mucosal immune responses without pulmonary immunopathologic injuries in mice.NPJ vaccines · 2025Article
- Respiratory delivered vaccines: Current status and perspectives in rational formulation design.Acta pharmaceutica Sinica. B · 2024Review
- Article
- Article
- A comprehensive review of oral microenvironment changes and orofacial adverse reactions after COVID-19 vaccination: The good, the bad, and the ugly.Health science reports · 2024Article
- A Meta-Analysis on the Association between Peptic Ulcer Disease and COVID-19 Severity.Vaccines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 5 institutions in 2 countries.
Masoud Solaymani DodaranClinical Trial Center, Iran University of Medical Science, Tehran 1449614535, Iran.
Seyed Reza BanihashemiDepartment of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Ali Es-HaghiDepartment of Physico Chemistry, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.ORCID 0000-0001-6533-3656
Mohammad Hossein Fallah MehrabadiDepartment of Epidemiology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Mojtaba NofeliDepartment of Research and Development, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Ali Rezaei MokarramDepartment of QA, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Ladan MokhberalsafaDepartment of Health, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj P.O. Box 31975/148, Iran.ORCID 0000-0002-9437-4067
Fariba SadeghiDepartment of Health, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj P.O. Box 31975/148, Iran.
Alireza RanjbarInstitute of Interventional Allergology and Immunology, Bonn/Cologne, 53115 Bonn, Germany.
Akram AnsarifarSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Arash MohazzabSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Seyed Amin SetarehdanMinimally Invasive Surgery Research Center, Hazrat-e-Rasool Hospital, Iran University of Medical Science, Tehran 1445613113, Iran.ORCID 0000-0003-0596-3175
Fahimeh Bagheri AmiriDepartment of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Vahideh MohseniSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Monireh HajimoradiDepartment of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Neda GhahremanzadehSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Seyed Hossein RazzazDepartment of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Safdar MasoomiDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran P.O. Box 14115/111, Iran.
Maryam TaghdiriDepartment of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Mohsen BagheriDepartment of Physico Chemistry, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Mohsen LoftiDepartment of QA, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Akbar KhorasaniDepartment of Research and Development, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Masoud GhaderDepartment of Physico Chemistry, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj P.O. Box 31975/148, Iran.
Shiva SafariSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Masumeh ShahsavnSchool of Public Health, Iran University of Medical Science, Tehran 1449614535, Iran.
Saeed KalantariDepartments of Infectious Diseases and Tropical Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Razi Vaccine and Serum Research Institute · IRIran University of Medical Sciences · IRPasteur Institute of Iran · IRTarbiat Modares University · IRUniversity of Nottingham · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
immune responseimmunogenicityintranasal vaccinerecombinant vaccineSARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.