Evidence map›Paper›PMID 36851324›Full record

ArticleVaccines2023

Neutralizing Antibodies as Predictors of Vaccine Breakthrough Infection in Healthcare Workers Vaccinated with or without a Heterologous Booster Dose: A Cohort Study during the Third COVID-19 Wave in Peru.

Miguel Hueda-Zavaleta, Juan C Gómez de la Torre, José Alonso Cáceres-DelAguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Cesar Copaja-Corzo, Carlos J Aragón-Ayala, Vicente A Benítes-Zapata

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Miguel Hueda-ZavaletaFacultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru.ORCID 0000-0002-8049-7787
Juan C Gómez de la TorreRoe Clinical Laboratory, Lima 15076, Peru.ORCID 0000-0003-4566-2027
José Alonso Cáceres-DelAguilaRoe Clinical Laboratory, Lima 15076, Peru.
Cecilia Muro-RojoRoe Clinical Laboratory, Lima 15076, Peru.
Nathalia De La Cruz-EscurraRoe Clinical Laboratory, Lima 15076, Peru.
Cesar Copaja-CorzoFacultad de Ciencias de la Salud, Universidad Científica del Sur, Lima 15842, Peru.ORCID 0000-0001-9982-5368
Carlos J Aragón-AyalaFacultad de Medicina, Universidad Nacional de San Agustin de Arequipa, Arequipa 04000, Peru.ORCID 0000-0001-9536-2247
Vicente A Benítes-ZapataUnidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima 15024, Peru.
Daniel Alcides Carrión National University · PEUniversidad Científica del Sur · PEUniversidad Nacional de San Agustin de Arequipa · PEUniversidad San Ignacio de Loyola · PE

Funding

Universidad Privada de Tacna 1Universidad San Ignacio de Loyola 2
6 · The paper itself

Abstract

We evaluated neutralizing antibody (NAbs) levels as a protective factor against vaccine breakthrough infection (VBI) in healthcare workers (HCWs) during the third COVID-19 wave in Peru. This retrospective cohort study employed the information from a private laboratory in Lima (Peru) of HCW who received only two BBIBP-CorV vaccines or (additionally) a heterologous booster with BNT162b2. We evaluated the association between the VBI and the levels of NAbs at 21, 90, 180, and 210 days after the BBIBP-CorV second dose. NAbs were calculated with the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit (surrogate virus neutralization test (sVNT)) and the Elecsys

Indexed as

COVID-19heterologous booster vaccinehumoral immunityneutralizing antibodySARS-CoV-2vaccine breakthrough infection

Identifiers

PMID36851324
PMCPMC9961465
OpenAlexW4320918726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.