Evidence map›Paper›PMID 36851311›Full record

ArticleVaccines2023

New Onset of Giant Cell Arteritis following ChAdOx1-S (Vaxevria

Luca Lo Sardo, Simone Parisi, Maria Chiara Ditto, Rosanna De Giovanni, Francesca Maletta, Serena Grimaldi, Luisa Brussino, Enrico Fusaro

Abstract readCase Reports
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luca Lo SardoUnit of Rheumatology, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.
Simone ParisiUnit of Rheumatology, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.
Maria Chiara DittoUnit of Rheumatology, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.ORCID 0000-0001-5025-287X
Rosanna De GiovanniUnit of Rheumatology, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.
Francesca MalettaPathology Unit, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.
Serena GrimaldiDivision of Nuclear Medicine, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.
Luisa BrussinoClinical Immunology and Allergy Unit, AO Ordine Mauriziano, 10128 Turin, Italy.ORCID 0000-0001-7249-7616
Enrico FusaroUnit of Rheumatology, "AOU Città della Salute e della Scienza" Hospital, 10126 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a 78-year-old man presenting with persistent headaches in vertex and temporo-parietal area; fatigue, worsening after walking; jaw claudication; scotomas; pharyngodynia; and dry cough after the second dose of the SARS-CoV-2 vaccine (ChAdOx1-S) administration. Laboratory findings showed an elevated C-reactive protein level and FDG-CT PET showed evidence of active large vessel vasculitis with diffuse abnormal artery uptake. Under suspicion of vasculitis, a temporal arteries biopsy was performed; the histopathologic findings demonstrated the transmural inflammatory infiltrate with giant cells, compatible with giant cell arteritis. Although the overall incidence of vaccine-triggered autoimmunity is low, rheumatologists worldwide should be aware of autoimmune diseases as a new potential adverse event of vaccines.

Indexed as

adverse eventsCOVID-19giant cell arteritisvaccines

Identifiers

PMID36851311
PMCPMC9964649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.