Evidence map›Paper›PMID 36851287›Full record

ArticleVaccines2023

COVID-19 Vaccine Status, Intent, Hesitancy, and Disease-Related Beliefs in People with Multiple Sclerosis.

Lisa Grech, Alastair Kwok, Mike Nguyen, Antony Winkel, Ernest Butler, Michelle Allan, Nathan Bain, Eva Segelov, On Behalf Of The Msvaccs Investigators

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Is there still hesitancy towards SARS-CoV-2 vaccination among people with neurological disease- a survey of the NeuroCOVID-19 task force of the European Academy of Neurology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lisa GrechDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
Alastair KwokDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
Mike NguyenDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
Antony WinkelDepartment of Neurology, Sunshine Coast Hospital and Health Service, Birtinya, QLD 4575, Australia.ORCID 0000-0002-6100-4764
Ernest ButlerDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
Michelle AllanMonash Neurology, Monash Health, Clayton, VIC 3168, Australia.ORCID 0000-0003-3523-6008
Nathan BainDepartment of Oncology, Monash Health, Clayton, VIC 3168, Australia.
Eva SegelovDepartment of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.ORCID 0000-0002-4410-6144
On Behalf Of The Msvaccs Investigators
Monash Health · AUGriffith University · AUMonash University · AUUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople with multiple sclerosis (MS) are susceptible to severe COVID-19 outcomes. They were included as a priority group for the Australian COVID-19 vaccine roll-out in early 2021. However, vaccine hesitancy remains a complex barrier to vaccination in this population group, which may be partly related to disease relapse concerns following COVID-19 vaccination. This study examined the COVID-19 vaccination status, intent, hesitancy, and disease-related beliefs in people with MS.

methodsAn online survey was conducted with people with MS receiving care at two Australian health services between September and October 2021. It collected sociodemographic and disease-specific characteristics and responses to validated scales that assessed vaccine hesitancy and general and MS-related vaccine beliefs.

resultsOf the 281 participants [mean age 47.7 (SD 12.8) years; 75.8% females], most (82.9%) had received at least one COVID-19 vaccine dose. Younger participants were less likely to be vaccinated, as were those within 1-5 years of disease duration. After controlling for age, disease duration was not associated with vaccination status. Unvaccinated participants were more likely to report less willingness to receive the COVID-19 vaccine, higher vaccine complacency and lower vaccine confidence, greater MS-related vaccine complacency, and higher MS and treatment interaction concerns.

conclusionsPeople with MS reported a high vaccination rate, despite general and MS-specific COVID-19 vaccine concerns. Greater MS-specific concerns were reported by those who indicated that their MS was not well-controlled and their MS impacted their daily activities. By understanding the factors that influence vaccine hesitancy and their interplay with MS disease course and treatment concerns, this can inform tailored interventions and educational messages to address these concerns in people with MS. Clinicians, governments, and community organisations are key partners in delivering these interventions and messages, as ongoing booster doses are needed for this vulnerable population.

Indexed as

COVID-19disease-related beliefsmultiple sclerosisvaccine hesitancyvaccine intent

Identifiers

PMID36851287
PMCPMC9964563
OpenAlexW4320491865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.