Evidence map›Paper›PMID 36851186›Full record

ReviewVaccines2023

Quasispecies Nature of RNA Viruses: Lessons from the Past.

Kiran Singh, Deepa Mehta, Shaurya Dumka, Aditya Singh Chauhan, Sachin Kumar

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kiran SinghDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.ORCID 0000-0003-0347-3906
Deepa MehtaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.ORCID 0000-0002-0455-1550
Shaurya DumkaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.ORCID 0000-0002-9683-3095
Aditya Singh ChauhanDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.ORCID 0000-0002-8702-7999
Sachin KumarDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.ORCID 0000-0002-8526-6013
Indian Institute of Technology Guwahati · IN

Funding

Department of Biotechnology BT/PR41246/NER/95/1685/2020Indian Council of Medical Research NER/71/2020-ECD-I
6 · The paper itself

Abstract

Viral quasispecies are distinct but closely related mutants formed by the disparity in viral genomes due to recombination, mutations, competition, and selection pressure. Theoretical derivation for the origin of a quasispecies is owed to the error-prone replication by polymerase and mutants of RNA replicators. Here, we briefly addressed the theoretical and mathematical origin of quasispecies and their dynamics. The impact of quasispecies for major salient human pathogens is reviewed. In the current global scenario, rapid changes in geographical landscapes favor the origin and selection of mutants. It comes as no surprise that a cauldron of mutants poses a significant risk to public health, capable of causing pandemics. Mutation rates in RNA viruses are magnitudes higher than in DNA organisms, explaining their enhanced virulence and evolvability. RNA viruses cause the most devastating pandemics; for example, members of the

Indexed as

antiviral treatmentslethal mutagenesismutant cloudquasispeciesvaccine

Identifiers

PMID36851186
PMCPMC9963406
OpenAlexW4318483974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.