Evidence map›Paper›PMID 36851058›Full record

ArticleToxics2023

Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat.

Huazhong Zhang, Jinsong Zhang, Jinquan Li, Zhengsheng Mao, Jian Qian, Cheng Zong, Hao Sun, Beilei Yuan

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Risk factors for death in patients with acute diquat poisoning.World journal of emergency medicine · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. [A Preliminary Study on the Plasma Metabolomic Profiles of Patients Suffering From Acute Diquat Poisoning].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Huazhong ZhangDepartment of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jinsong ZhangDepartment of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jinquan LiDepartment of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhengsheng MaoInstitute of Poisoning, Nanjing Medical University, Nanjing 211100, China.
Jian QianDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Cheng ZongCollege of Safety Science and Engineering, Nanjing Tech University, Nanjing 211816, China.
Hao SunDepartment of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Beilei YuanCollege of Safety Science and Engineering, Nanjing Tech University, Nanjing 211816, China.ORCID 0000-0002-1679-2028
Jiangsu Province Hospital · CNNanjing Tech University · CNNanjing Medical University · CN

Funding

Key Clinical Specialty Project Su Finance (2020) No. 155National Natural Science Foundation of China 81803274National Natural Science Foundation of China 82072158Young Scholars Fostering Fund of the First Affiliated Hospital of Nanjing Medical University. 47
6 · The paper itself

Abstract

Diquat (DQ), a widely used bipyridyl herbicide, is associated with significantly higher rates of kidney injuries compared to other pesticides. However, the underlying molecular mechanisms are largely unknown. In this study, we identified the molecular changes in the early stage of DQ-induced kidney damage in a mouse model through transcriptomic, proteomic and metabolomic analyses. We identified 869 genes, 351 proteins and 96 metabolites that were differentially expressed in the DQ-treated mice relative to the control mice (

Indexed as

diquatfatty acid metabolismkidney injurymulti-omicsPPAR signaling pathway

Identifiers

PMID36851058
PMCPMC9966843
OpenAlexW4321107452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.