Evidence map›Paper›PMID 36851005›Full record

ArticleToxics2023

Determination of Parabens and Their Metabolites in Seminal Plasma from Chinese Men by Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS).

Jing Dai, Linyuan Zhang, Jianfeng Xu, Fangda Peng, Zhijun Wu, Longlong Fu, Ying Guo, Bing Chang, Wenhong Lu, Chunguang Ding

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jing DaiNational Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.
Linyuan ZhangNational Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Jianfeng XuNational Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction, Beijing 100081, China.
Fangda PengNational Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.
Zhijun WuNational Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Longlong FuNational Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction, Beijing 100081, China.
Ying GuoNational Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction, Beijing 100081, China.
Bing ChangNational Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Wenhong LuNational Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction, Beijing 100081, China.
Chunguang DingNational Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.
National Health and Family Planning Commission · CNNational Institute for Occupational Health and Poison Control · CN

Funding

National Natural Science Foundation of China 21907021the Project of National Center for Occupational Safety and Health, National Health Commission of the People's Republic of China 2019009
6 · The paper itself

Abstract

Parabens are endocrine-disrupting chemicals (EDCs) that have estrogen-like activities and may cause male reproductive disorders. Here, we developed a method for the simultaneous determination of four parabens (MeP, EtP, n-PrP, n-BuP) and two metabolites (4-HB and 3,4-DHB) in human seminal plasma by UPLC-MS/MS. The method was used to analyze 144 seminal plasma samples from Chinese males. MeP, EtP, n-PrP, and 4-HB were the dominant compounds. MeP, EtP, and n-PrP were significantly correlated to each other. In addition, 4-HB was significantly correlated to MeP, EtP, n-PrP, and 3,4-DHB, respectively. The results provide direct evidence that parabens and their metabolites are widely distributed in the male reproductive system. The study presents the paraben metabolites levels in human seminal plasma for the first time.

Indexed as

metaboliteparabensseminal plasmaUPLC-MS/MS

Identifiers

PMID36851005
PMCPMC9962888
OpenAlexW4318472756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.