Evidence map›Paper›PMID 36850363›Full record

ArticleSensors (Basel, Switzerland)2023

An Explainable Spatial-Temporal Graphical Convolutional Network to Score Freezing of Gait in Parkinsonian Patients.

Hyeokhyen Kwon, Gari D Clifford, Imari Genias, Doug Bernhard, Christine D Esper, Stewart A Factor, J Lucas McKay

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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  6. Gait-Guard: Turn-aware Freezing of Gait Detection for Non-intrusive Intervention Systems....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyeokhyen KwonDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-5693-3278
Gari D CliffordDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-5709-201X
Imari GeniasDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-2490-8817
Doug BernhardJean and Paul Amos Parkinson's Disease and Movement Disorders Program, Department of Neurology, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Christine D EsperJean and Paul Amos Parkinson's Disease and Movement Disorders Program, Department of Neurology, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-1093-6537
Stewart A FactorJean and Paul Amos Parkinson's Disease and Movement Disorders Program, Department of Neurology, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-0449-973X
J Lucas McKayDepartment of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-8361-8943
Emory University · US

Funding

Neural mechanisms of balance deficits, falls, and freezing of gait in Parkinson's diseaseK25HD086276 · NICHD · EMORY UNIVERSITY · PI MCKAY, JOHNATHAN LUCAS · 2016 to 2019
$509k
NICHD NIH HHS K25 HD086276
6 · The paper itself

Abstract

Freezing of gait (FOG) is a poorly understood heterogeneous gait disorder seen in patients with parkinsonism which contributes to significant morbidity and social isolation. FOG is currently measured with scales that are typically performed by movement disorders specialists (i.e., MDS-UPDRS), or through patient completed questionnaires (N-FOG-Q) both of which are inadequate in addressing the heterogeneous nature of the disorder and are unsuitable for use in clinical trials The purpose of this study was to devise a method to measure FOG objectively, hence improving our ability to identify it and accurately evaluate new therapies. A major innovation of our study is that it is the first study of its kind that uses the largest sample size (>30 h, N = 57) in order to apply explainable, multi-task deep learning models for quantifying FOG over the course of the medication cycle and at varying levels of parkinsonism severity. We trained interpretable deep learning models with multi-task learning to simultaneously score FOG (cross-validated F1 score 97.6%), identify medication state (OFF vs. ON levodopa; cross-validated F1 score 96.8%), and measure total PD severity (MDS-UPDRS-III score prediction error ≤ 2.7 points) using kinematic data of a well-characterized sample of N = 57 patients during levodopa challenge tests. The proposed model was able to

Indexed as

Gait Disorders, NeurologicParkinson DiseaseGaitHumansLevodopaMovementLevodopadeep learningmotion capturemulti-task learningParkinson’s disease

Identifiers

PMID36850363
PMCPMC9968199
OpenAlexW4319320420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.