ArticleBMC neurology2023
Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage.
Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of PCSK9 inhibitor evolocumab on preventing early neurological deterioration in acute ischemic stroke patients with or without large artery atherosclerosis: a subgroup analysis of a randomized trial.BMC neurology · 2025 · on this mapTrial
- Trial
- Influence of PCSK9 inhibitors on early neurological function, inflammatory factors and blood lipids in patients with acute cerebral infarction: a retrospective cohort study.BMC neurology · 2026Article
- Mechanism-Oriented Treatment of Early Neurologic Deterioration in Acute Ischemic Stroke.Journal of stroke · 2026Review
- Contralateral hemispheric cerebral blood flow can predict short-term clinical outcomes in patients with recent small subcortical infarcts.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Healthcare professionals' knowledge, attitudes, and practices towards predictive diagnosis of early neurological deterioration.Scientific reports · 2025Article
- Clinical and imaging risk factors for early neurological deterioration and long-term neurological disability in patients with single subcortical small infarction.BMC neurology · 2025Article
- Impact of Onset-to-Needle Time on the Risk of Early Neurological Deterioration in Patients with Acute Ischemic Stroke Receiving Intravenous Thrombolysis.Therapeutics and clinical risk management · 2025Article
- Interpretable machine learning for predicting early neurological deterioration in symptomatic intracranial atherosclerotic stenosis.Frontiers in neurology · 2025Article
- Prediction of early neurologic deterioration in patients with perforating artery territory infarction using machine learning: a retrospective study.Frontiers in neurology · 2024Article
- Predictive factors for early neurological deterioration after intravenous thrombolysis of single subcortical infarction in the territory of the middle cerebral artery.Brain and behavior · 2023Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study aimed to assess the epidemiological features and explore the potential risk factors for early neurological deterioration (END) in patients with acute single small subcortical infarction (SSSI) who underwent antiplatelet therapy without carotid artery stenosis. MATERIALS &
methodsPatients with SSSI, as confirmed by cranial magnetic resonance imaging (MRI), who were hospitalized within 48 h after the onset of symptoms were enrolled. END was mainly defined as increment in the National Institutes of Health Stroke Scale (NIHSS) score of ≥ 2 points or any new neurological deficit. Poor functional outcome was defined as modified Rankin Scale (mRS) score of > 2 points at 3-month after the onset. The association of END with multiple indicators was assessed at the early stage of admission using multivariate logistic regression analysis, and adjusted odds ratios (aORs) were calculated.
resultsA total of 280 patients were enrolled from June 2020 to May 2021, of whom, END occurred in 44 (15.7%) patients (median age, 64 years; 70.5% male), while END occurred during sleep in 28 (63.6%) patients. History of hypertension (aOR: 4.82, p = 0.001), infarction in internal capsule (aOR: 3.35, p = 0.001), and elevated level of low-density lipoprotein cholesterol (LDL-C; aOR: 0.036, p = 0.0016) were significantly associated with the risk of END. Patients with END (aOR: 5.74, p = 0.002), history of diabetes (aOR: 2.61, p = 0.020), and higher NIHSS scores at discharge (per 1-score increase, aOR: 1.29, p = 0.026) were associated with the poor functional outcome at 3-month after the onset.
conclusionPatients with a history of hypertension, infarction in internal capsule or a higher level of LDL-C were found to be at a higher risk of END.
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