Evidence map›Paper›PMID 36849678›Full record

Trial reportGeroScience2023

Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16

Judith E Carroll, Richard Olmstead, Steve W Cole, Elizabeth C Breen, Jesusa M Arevalo, Michael R Irwin

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Judith E CarrollCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA. jcarroll@mednet.ucla.edu.ORCID 0000-0001-5516-0819
Richard OlmsteadCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Steve W ColeCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Elizabeth C BreenCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Jesusa M ArevaloCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Michael R IrwinCousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, USA.
Howard Hughes Medical Institute · USUniversity of California, Los Angeles · US

Funding

Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
A Randomized Trial for Sleep Disturbances to Reverse Cellular AgingR01AG052655 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E · 2016 to 2019
$1.5M
NIA NIH HHS R01 AG026364NIA NIH HHS R01AG026364NIA NIH HHS R01 AG052655NIA NIH HHS R01AG052655
6 · The paper itself

Abstract

Late life insomnia may increase risk for accelerated biological aging. Intervening to treat insomnia may provide protection from biological aging by reducing the prevalence of senescent cells in the immune system, as indicated by gene expression of a marker of cellular senescence, p16

Indexed as

Cognitive Behavioral TherapySleep Initiation and Maintenance DisordersAgedCyclin-Dependent Kinase Inhibitor p16Gene ExpressionHumansLeukocytes, MononuclearTreatment OutcomeCyclin-Dependent Kinase Inhibitor p16AgingCognitive behavioral therapyInsomniaInterventionRemissionSenescence

Identifiers

PMID36849678
PMCPMC10651570
OpenAlexW4322487224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.