Evidence map›Paper›PMID 36849662›Full record

ArticleAesthetic plastic surgery2023

Concentrated Growth Factor (CGF): The Newest Platelet Concentrate and Its Application in Nasal Hyaluronic Acid Injection Complications.

Hongfan Ding, Qiang Fu, Bing Liu, Xiao Xv, Guiwen Zhou, Can Zheng, Zhaoyang Chen, Minliang Chen

Abstract read
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In one paragraph

Article in Aesthetic plastic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Advances in Research on Concentrated Growth Factor Applications for Androgenetic Alopecia Treatment: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  3. Article
  4. Article
  5. The Application of Blood Products in Plastic Surgery: A Systematic Review.Plastic and reconstructive surgery. Global open · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hongfan Ding *Senior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Qiang Fu *Senior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Bing Liu *Private Practice, Shahekou district, Dalian, Liaoning, China.
Xiao XvSenior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Guiwen ZhouSenior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Can ZhengSenior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Zhaoyang ChenSenior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China.
Minliang ChenSenior Department of Burns and Plastic Surgery, the Fourth Medical Center, PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100038, China. chenml@sohu.com.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral cases of wounds caused by vascular compromise after facial cosmetic injection have been reported in recent years. How to promote wound healing, restore facial appearance, and avoid secondary injury in such patients have remained a clinical challenge. Our study was designed to assess the effect of concentrated growth factor (CGF) for repairing nasal wounds after nasal hyaluronic acid injection.

methodsSix women with nasal wounds after hyaluronic acid injection were enrolled from June 2019 to June 2022. The average time of the first CGF treatment from admission was 2-4 days. CGF gel was prepared from each patient's blood by using a Medifuge™ system. After debridement of the wound, the prepared CGF gel was applied on the wound surface, and the wound dressing was fixed to stabilize the CGF gel. The CGF treatment interval was 3-4 days.

resultsThe wound began to heal after the first CGF treatment. After 2-3 CGF treatments, the wound was almost completely healed. There was no deflection of the nasal columella, and nasal ventilation function was good. There was no obvious deformity in the appearance of the nose. After follow-up ranging from 2 months to 1 year, the appearance and function of the nose showed satisfactory recovery.

conclusionsCGF has great potential in promoting wound healing and restoring the appearance after complications from nasal hyaluronic acid injection. The preparation of CGF gel is simple, and the clinical application is convenient and safe. In future, more clinical trials are needed to further prove the efficacy and safety of CGF in the treatment of wounds secondary to cosmetic injection. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 .

Indexed as

Drug-Related Side Effects and Adverse ReactionsHyaluronic AcidFemaleHumansIntercellular Signaling Peptides and ProteinsNasal SeptumSkinTreatment OutcomeWound HealingHyaluronic AcidIntercellular Signaling Peptides and ProteinsComplicationConcentrated growth factorHyaluronic acidWound healing

Identifiers

PMID36849662
OpenAlexW4322492186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.