ArticleThe ISME journal2023
Mining chicken ileal microbiota for immunomodulatory microorganisms.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 50 citations in OpenAlex.
- Dietary α-Mangostin alleviates lipopolysaccharide-induced stress and enhances growth performance in broilers via improved intestinal immunity and integrity.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Machine learning identifies key microbial signatures for Salmonella enteritidis colonization and persistence in broiler ceca.Poultry science · 2026Article
- Evaluation of the jejunal microbiota and microbial markers in laying hens fed diets with black soldier fly larval fat as a partial or total replacement for soybean oil.Poultry science · 2026Article
- Developmental dynamics of crop morphology, microbiota, and mucosal immunity in chickens.Journal of animal science and biotechnology · 2026Article
- Gut microbial community assembly exhibits compartment-specific responses to selection for high body weight in female chickens.Poultry science · 2026Article
- Blautia Coccoides CML164 Improved Lipid and Energy Metabolism in Broiler Chickens Via Gut Microbiota Pathways.Probiotics and antimicrobial proteins · 2026Article
- Enterococcus faecalis GP1764 induces an early differential gene expression in the intestine on key pathways related to cellular immune response and gut barrier function in chickens.Poultry science · 2026Article
- Gut microbiota signatures associated with the development of Salmonella Typhimurium super-shedders in broiler chickens.Poultry science · 2026Article
- Longitudinal analysis of broiler cecal microbiome: unraveling the species level dynamics across age and sex.Poultry science · 2026Article
- Article
- Early gut microbiota transplantation in broiler chicks exerts effects on intestinal health depending on the donor's microbial composition.Poultry science · 2026Article
- Establishment of In OvoAnimals : an open access journal from MDPI · 2026Article
- Dismissing-then-recruiting: a unique mechanism for symbiont recruitment and lignocellulose degradation in gut of black soldier fly larvae.Microbiome · 2026Article
- Integrated omics analysis reveals the age-dependent dynamic changes of gut microbiota and metabolites in layer chickens.Poultry science · 2026Article
- Emerging technologies in poultry genomics: Unlocking innovation for the future of sustainable production.Poultry science · 2026Review
- Evaluating the Immunogenicity and Protective Efficacy of a Novel Vaccine Candidate AgainstVaccines · 2026Article
- Article
- Antibiotic growth promoter and phytogenic feed additive consistently alter microbial community structure in chicken cecum.Frontiers in microbiology · 2026Article
- High-zinc diets accelerate molting and recovery by remodeling the cecal microbiome in laying hens.Frontiers in microbiology · 2026Article
- Effect ofAnimals : an open access journal from MDPI · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota makes important contributions to host immune system development and resistance to pathogen infections, especially during early life. However, studies addressing the immunomodulatory functions of gut microbial individuals or populations are limited. In this study, we explore the systemic impact of the ileal microbiota on immune cell development and function of chickens and identify the members of the microbiota involved in immune system modulation. We initially used a time-series design with six time points to prove that ileal microbiota at different succession stages is intimately connected to immune cell maturation. Antibiotics perturbed the microbiota succession and negatively affected immune development, whereas early exposure to the ileal commensal microbiota from more mature birds promoted immune cell development and facilitated pathogen elimination after Salmonella Typhimurium infection, illustrating that early colonization of gut microbiota is an important driver of immune development. Five bacterial strains, Blautia coccoides, Bacteroides xylanisolvens, Fournierella sp002159185, Romboutsia lituseburensis, and Megamonas funiformis, which are closely related to the immune system development of broiler chickens, were then screened out and validated for their immunomodulatory properties. Our results provide insight into poultry immune system-microbiota interactions and also establish a foundation for targeted immunological interventions aiming to combat infectious diseases and promote poultry health and production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.