Evidence map›Paper›PMID 36849501›Full record

ArticleScientific reports2023

Structural basis for the toxic activity of MafB2 from maf genomic island 2 (MGI-2) in N. meningitidis B16B6.

So Hyeon Park, Sun Ju Jeong, Sung Chul Ha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

So Hyeon Park *Beamline Department, Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Sun Ju Jeong *Beamline Department, Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Sung Chul HaBeamline Department, Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea. scha2@postech.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Maf polymorphic toxin system is involved in conflict between strains found in pathogenic Neisseria species such as Neisseria meningitidis and Neisseria gonorrhoeae. The genes encoding the Maf polymorphic toxin system are found in specific genomic islands called maf genomic islands (MGIs). In the MGIs, the MafB and MafI encode toxin and immunity proteins, respectively. Although the C-terminal region of MafB (MafB-CT) is specific for toxic activity, the underlying enzymatic activity that renders MafB-CT toxic is unknown in many MafB proteins due to lack of homology with domain of known function. Here we present the crystal structure of the MafB2-CT

Indexed as

Genomic IslandsNeisseria meningitidisAnimalsInterleukin-6MiceNeisseriaProto-Oncogene Proteins c-mafRibonucleasesInterleukin-6Maf protein, mouseProto-Oncogene Proteins c-mafRibonucleases

Identifiers

PMID36849501
PMCPMC9970974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.