ArticleCell discovery2023
Excess folic acid intake increases DNA de novo point mutations.
Abstract readLetter
In one paragraph
Article in Cell discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Optimal folic acid dosage in lowering homocysteine: Precision Folic Acid Trial to lower homocysteine (PFAT-Hcy).European journal of nutrition · 2024Trial
- Pro-Carcinogenic Implications of Folic Acid Supplementation During Chemically Induced Cutaneous Squamous Cell Carcinoma in Mice.Journal of biochemical and molecular toxicology · 2026Article
- Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans.EMBO molecular medicine · 2026Article
- The FOLR2-IRF2BP2 axis mediates erythropoiesis impairment by excess folic acid in myelodysplastic neoplasms.Leukemia · 2026Article
- Folic acid ameliorates placental structure and function in fetal growth restriction via epigenetic modifications.Clinical epigenetics · 2025Article
- Folic acid improves intestinal function in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Fortification, folate and vitamin B12 balance, and the nervous system. Is folic acid excess potentially harmful?European journal of clinical nutrition · 2025Review
- Article
- Human organoids potentially boost research into environmental factors of neural tube defects.Reproductive toxicology (Elmsford, N.Y.) · 2025Review
- Unravelling lumbar disc herniation severity beyond MRI : integrated transcriptomic and metabolomic analyses highlight glycerophospholipid metabolism and inform a machine-learning diagnostic model: a pilot study.Bone & joint research · 2025Article
- The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development.EMBO reports · 2025Article
- High-dose folic acid use and cancer risk in women who have given birth: A register-based cohort study.Epilepsia · 2025Article
- Exploration of folate and its derivatives in grains of wheat with different colors.Frontiers in genetics · 2025Article
- MASLD: insights on the role of folate in hepatic lipid metabolism.Frontiers in nutrition · 2025Review
- Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study.Food & nutrition research · 2025Article
- Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Article
- Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.JAMA network open · 2024Article
- Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Xuanye Cao *Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Jianfeng Xu *Division of Biostatistics, Dan L. Duncan Cancer and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Ying L Lin *Center for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Robert M CabreraCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
Chaofan ZhangDepartments of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
John W SteeleCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Xiao HanCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
Bogdan J WlodarczykCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
James R LupskiDepartments of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Wei LiDivision of Biostatistics, Dan L. Duncan Cancer and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9931-5990
Hongyan WangObstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Key Laboratory of Reproduction Regulation of NPFPC, Children Hospital, Fudan University, Shanghai, China. wanghy@fudan.edu.cn.
Richard H FinnellCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Richard.Finnell@bcm.edu.ORCID http://orcid.org/0000-0002-5962-8754
Yunping LeiCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Yunping.lei@bcm.edu.
Funding
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MRisk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2011 to 2020
$12.6MINTERVENTION STRATEGIES FOR NON-FOLATE RESPONSIVE NEURAL TUBE DEFECTSR01HD083809 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H. · 2016 to 2024
$5.1MBiomechanics of Neural Tube Development using Brillouin-OCT MultimodalityR01HD095520 · NICHD · UNIVERSITY OF HOUSTON · PI FINNELL, RICHARD H., LARIN, KIRILL V · 2018 to 2022
$3.3MRole of Slc25a32 and Its Interaction with Lrp6 in the Etiology of Neural Tube DefectsR01HD100535 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI FINNELL, RICHARD H., LEI, YUNPING · 2020 to 2024
$2.9MTraining in Precision Environmental Health SciencesT32ES027801 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2018 to 2026
$2.8MMetabolic remodeling of skeletal muscle in mitochondrial myopathiesR01AR076029 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, D'AURELIO, MARILENA · 2020 to 2024
$2.7MFolic Acid, Parental Mutation Rates and the Risk for Neural Tube DefectsR01HD081216 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H., LEI, YUNPING · 2015 to 2019
$2.5MThe Role of GPR161 in the Etiology of Neural Tube DefectsR01HD093758 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI FINNELL, RICHARD H., KIM, SUNG EUN · 2018 to 2022
$1.9MPho-m6A assay: A phosphoselective method to quantify dynamics of m6A in mRNAR21ES032347 · NIEHS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, JAFFREY, SAMIE R · 2020 to 2021
$466kPathogenic Linking of HIV Integrase Inhibitors, Folate Receptors, and Cerebral Folate DeficiencyR21MH122252 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI CABRERA, ROBERT M · 2019 to 2020
$440kNIAMS NIH HHS R01 AR076029NICHD NIH HHS P01 HD067244NICHD NIH HHS R01 HD081216NICHD NIH HHS R01 HD083809NICHD NIH HHS R01 HD093758NICHD NIH HHS R01 HD095520NICHD NIH HHS R01 HD100535NIEHS NIH HHS R21 ES032347NIEHS NIH HHS T32 ES027801NIMH NIH HHS R21 MH122252
Abstract
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