Evidence map›Paper›PMID 36849436›Full record

ArticleAutophagy2023

Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis.

Yong-Woo Jun, Soojin Lee, Byung-Kwan Ban, Jin-A Lee, Fen-Biao Gao

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yong-Woo JunDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Soojin LeeDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Byung-Kwan BanDepartment of Biotechnology and Biological Sciences, Hannam University, Yuseong-gu, Daejeon, Republic of Korea.
Jin-A LeeDepartment of Biotechnology and Biological Sciences, Hannam University, Yuseong-gu, Daejeon, Republic of Korea.
Fen-Biao GaoDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
University of Massachusetts Chan Medical School · USHannam University · KR

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
NINDS NIH HHS R01 NS101986NINDS NIH HHS R37 NS057553
6 · The paper itself

Abstract

Dysfunction of the endosomal sorting complex required for transport (ESCRT) has been linked to frontotemporal dementia (FTD) due in part to the accumulation of unsealed autophagosomes. However, the mechanisms of ESCRT-mediated membrane closure events on phagophores remain largely unknown. In this study, we found that partial knockdown of non-muscle MYH10/myosin IIB/zip rescues neurodegeneration in both

Indexed as

AutophagosomesFrontotemporal DementiaAutophagyEndosomal Sorting Complexes Required for TransportHomeostasisHumansNeuronsNonmuscle Myosin Type IIBEndosomal Sorting Complexes Required for TransportNonmuscle Myosin Type IIBAutophagyDrosophilaESCRTmitophagymyosin IIneurodegenerationneuron

Identifiers

PMID36849436
PMCPMC10283425
OpenAlexW4322617168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.