Evidence map›Paper›PMID 36849329›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2023

Recruiting for a Randomized Clinical Trial for Late-Life Depression During COVID-19: Outcomes of Provider Referrals Versus Facebook Self-Referrals.

Nicholas J Ainsworth, Hailey Wright, Ksenya Tereshchenko, Daniel M Blumberger, Alastair J Flint, Eric J Lenze, Athina Perivolaris, Benoit H Mulsant

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas J AinsworthCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto ON, Canada. Electronic address: nickjainsworth@alumni.ubc.ca.
Hailey WrightCentre for Addiction and Mental Health, Toronto, ON, Canada.
Ksenya TereshchenkoCentre for Addiction and Mental Health, Toronto, ON, Canada.
Daniel M BlumbergerCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto ON, Canada.
Alastair J FlintDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto ON, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Eric J LenzeDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO.
Athina PerivolarisCentre for Addiction and Mental Health, Toronto, ON, Canada.
Benoit H MulsantCentre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto ON, Canada.

Funding

2/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depression.R01MH114980 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, PATRICK J, RUTHERFORD, BRET R · 2017 to 2021
$1.8M
NIMH NIH HHS R01 MH114980
6 · The paper itself

Abstract

objectiveTo evaluate the effectiveness of online recruitment for a clinical trial of pharmacotherapy for late-life depression during COVID-19.

methodsThe authors calculated the yield, defined as recruitment leading to randomization (enrollment), from provider referrals versus Facebook self-referrals; compared characteristics and drop-out rates of participants from each source; and analyzed correlations between stringency of public health restrictions and referrals from each source over time.

resultsProvider referrals had a significantly higher yield (10 of 33 referrals; 30.3%) versus Facebook self-referrals (14 of 323; 4.3%) (p <0.00001). Participants self-referred from Facebook had significantly more education; otherwise, both groups had similar characteristics and drop-out rates. While public health stringency was negatively correlated with provider referrals (ρ = -0.32) and positively correlated with Facebook self-referrals (ρ = 0.39), neither association reached statistical significance.

conclusionOnline recruitment may improve access to clinical research for older depressed adults. Future studies should evaluate cost-effectiveness and potential barriers such as computer literacy.

Indexed as

COVID-19Social MediaDepressionHumansPatient SelectionReferral and Consultationagingclinical researchCOVID-19Depressionvirtual care

Identifiers

PMID36849329
PMCPMC9893767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.