Evidence map›Paper›PMID 36849252›Full record

ArticleLife science alliance2023

Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer.

Tamara Göbel, Bjarne Goebel, Marius Hyprath, Ira Lamminger, Hannah Weisser, Carlo Angioni, Marius Mathes, Dominique Thomas, Astrid S Kahnt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tamara GöbelInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Bjarne GoebelInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Marius HyprathInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Ira LammingerInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Hannah WeisserInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Carlo AngioniInstitute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Goethe University, Frankfurt, Germany.
Marius MathesInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
Dominique ThomasInstitute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Goethe University, Frankfurt, Germany.
Astrid S KahntInstitute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany kahnt@pharmchem.uni-frankfurt.de.ORCID https://orcid.org/0000-0001-6166-0940
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The leukotriene (LT) pathway is positively correlated with the progression of solid malignancies, but the factors that control the expression of 5-lipoxygenase (5-LO), the central enzyme in LT biosynthesis, in tumors are poorly understood. Here, we report that 5-LO along with other members of the LT pathway is up-regulated in multicellular colon tumor spheroids. This up-regulation was inversely correlated with cell proliferation and activation of PI3K/mTORC-2- and MEK-1/ERK-dependent pathways. Furthermore, we found that

Indexed as

Arachidonate 5-LipoxygenaseColonic NeoplasmsHumansLipid MetabolismMechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasesArachidonate 5-LipoxygenaseMechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-Kinases

Identifiers

PMID36849252
PMCPMC9971161
OpenAlexW4322490231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.