Evidence map›Paper›PMID 36848720›Full record

ArticleMedical image analysis2023

Dense regression activation maps for lesion segmentation in CT scans of COVID-19 patients.

Weiyi Xie, Colin Jacobs, Jean-Paul Charbonnier, Bram van Ginneken

Open access · hybridAbstract read
In one paragraph

Article in Medical image analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Osegnet-F-Unext: O-Segnet-Fusion-Unext for pulmonary lobe segmentation of Covid-19 using Computed Tomography image.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  4. Weakly-Supervised Segmentation-Based Quantitative Characterization of Pulmonary Cavity Lesions in CT Scans.IEEE journal of translational engineering in health and medicine · 2024
    Article
  5. Automatic Quantification of COVID-19 Pulmonary Edema by Self-supervised Contrastive Learning.Medical image learning with limited and noisy data : second international workshop, MILLanD 2023, held in conjunction with MICCAI 2023, Vancouver, BC, Canada, October 8, 2023, proceedings. MILLanD (Workshop) : (2nd : 2023 : Vancouver, B... · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Weiyi XieThe Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands. Electronic address: weiyi.xie@radboudumc.nl.
Colin JacobsThe Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Jean-Paul CharbonnierThirona, 6525 EC Nijmegen, The Netherlands.
Bram van GinnekenThe Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Automatic lesion segmentation on thoracic CT enables rapid quantitative analysis of lung involvement in COVID-19 infections. However, obtaining a large amount of voxel-level annotations for training segmentation networks is prohibitively expensive. Therefore, we propose a weakly-supervised segmentation method based on dense regression activation maps (dRAMs). Most weakly-supervised segmentation approaches exploit class activation maps (CAMs) to localize objects. However, because CAMs were trained for classification, they do not align precisely with the object segmentations. Instead, we produce high-resolution activation maps using dense features from a segmentation network that was trained to estimate a per-lobe lesion percentage. In this way, the network can exploit knowledge regarding the required lesion volume. In addition, we propose an attention neural network module to refine dRAMs, optimized together with the main regression task. We evaluated our algorithm on 90 subjects. Results show our method achieved 70.2% Dice coefficient, substantially outperforming the CAM-based baseline at 48.6%. We published our source code at https://github.com/DIAGNijmegen/bodyct-dram.

Indexed as

COVID-19AlgorithmsHumansImage Processing, Computer-AssistedNeural Networks, ComputerTomography, X-Ray ComputedClass activation mapComputed tomographyCOVID-19Dense regression activation mapMedical imagingWeakly-supervised semantic segmentation

Identifiers

PMID36848720
PMCPMC9933523
OpenAlexW4321072203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.