Evidence map›Paper›PMID 36848718›Full record

ArticleDevelopmental cognitive neuroscience2023

The Oregon ADHD-1000: A new longitudinal data resource enriched for clinical cases and multiple levels of analysis.

Joel T Nigg, Sarah L Karalunas, Michael A Mooney, Beth Wilmot, Molly A Nikolas, Michelle M Martel, Jessica Tipsord, Elizabeth K Nousen, Colleen Schmitt, Peter Ryabinin and 3 more

Abstract read
In one paragraph

Article in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Reproducible Temperament Profiles in Adolescents With Attention-Deficit/Hyperactivity Disorder Prospectively Predict Clinical Outcomes.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Exploring Transdiagnostic Mechanisms of Youth Externalizing Psychopathology: A Longitudinal Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  7. Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026
    Article
  8. The Evolving ADHD Phenotype in the Externalizing Context.The American journal of psychiatry · 2026
    Review
  9. Cognition varies across the calendar year in multiple large-scale datasets.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Developmental Pathways of Inattention, Hyperactivity/Impulsivity, and Disruptive Behaviors: A Longitudinal, Person-Centered Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joel T NiggDepartment of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, USA. Electronic address: niggj@ohsu.edu.
Sarah L KaralunasDepartment of Psychological Sciences, Purdue University, USA.
Michael A MooneyDepartment of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, USA.
Beth WilmotOregon Clinical and Translational Research Institute, Oregon Health & Science University, USA.
Molly A NikolasDepartment of Psychological and Brain Sciences, University of Iowa, USA.
Michelle M MartelDepartment of Psychology, University of Kentucky, USA.
Jessica TipsordDepartment of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, USA.
Elizabeth K NousenDepartment of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, USA.
Colleen SchmittDepartment of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, USA.
Peter RyabininKnight Cancer Institute, Oregon Health & Science University, USA.
Erica D MusserDepartment of Psychology, Florida International University, USA.
Bonnie J NagelDepartment of Psychiatry & Behavioral Neuroscience, Oregon Health & Science University, USA.
Damien A FairDepartment of Pediatrics, Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, University of Minnesota, USA. Electronic address: faird@umn.edu.

Funding

Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4M
ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
ADHD biotypes using genetic and imaging approachesR01MH099064 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2013 to 2017
$3.2M
Polygenic and environmental contributions to ADHD trajectory and outcome from childhood through adolescenceR01MH131685 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Michael A Mooney, Molly Nikolas · 2023 to 2026
$3.1M
Longitudinal Imaging Study of ADHD Brain DevelopmentR01MH086654 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2010 to 2014
$2.9M
Genetics of ADHD: Haplotype and Endophenotype ApproachesR01MH070004 · NIMH · MICHIGAN STATE UNIVERSITY · PI FRIDERICI, KAREN H. · 2005 to 2009
$2.1M
Neurophysiological mechanisms of cognitive and emotional control in ADHDK23MH108656 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI KARALUNAS, SARAH LYN · 2016 to 2019
$742k
NIMH NIH HHS K23 MH108656NIMH NIH HHS R01 MH070004NIMH NIH HHS R01 MH086654NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH099064NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH131685NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

The fields of developmental psychopathology, developmental neuroscience, and behavioral genetics are increasingly moving toward a data sharing model to improve reproducibility, robustness, and generalizability of findings. This approach is particularly critical for understanding attention-deficit/hyperactivity disorder (ADHD), which has unique public health importance given its early onset, high prevalence, individual variability, and causal association with co-occurring and later developing problems. A further priority concerns multi-disciplinary/multi-method datasets that can span different units of analysis. Here, we describe a public dataset using a case-control design for ADHD that includes: multi-method, multi-measure, multi-informant, multi-trait data, and multi-clinician evaluation and phenotyping. It spans > 12 years of annual follow-up with a lag longitudinal design allowing age-based analyses spanning age 7-19 + years with a full age range from 7 to 21. Measures span genetic and epigenetic (DNA methylation) array data; EEG, functional and structural MRI neuroimaging; and psychophysiological, psychosocial, clinical and functional outcomes data. The resource also benefits from an autism spectrum disorder add-on cohort and a cross sectional case-control ADHD cohort from a different geographical region for replication and generalizability. Datasets allowing for integration from genes to nervous system to behavior represent the "next generation" of researchable cohorts for ADHD and developmental psychopathology.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAdolescentAdultChildCross-Sectional StudiesHumansOregonReproducibility of ResultsYoung AdultAttention-deficit/hyperactivity disorderCase-control longitudinalDesignGenetic and epigenetic arrayNeuroimagingPublic datasetPyschophysiological

Identifiers

PMID36848718
PMCPMC9984785

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.