Evidence map›Paper›PMID 36848685›Full record

ArticleACS biomaterials science & engineering2023

Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting.

Francesca Perin, Eugenia Spessot, Anna Famà, Alessio Bucciarelli, Emanuela Callone, Carlos Mota, Antonella Motta, Devid Maniglio

Full text read
In one paragraph

Article in ACS biomaterials science & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. MXene Bioinks for 3D Bioprinting: Design and Translation.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Silk fibroin-based inks forBioactive materials · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca PerinDepartment of Industrial Engineering and BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Eugenia SpessotDepartment of Industrial Engineering and BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-8367-7847
Anna FamàDepartment of Industrial Engineering and BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Alessio BucciarelliLaboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy.ORCID 0000-0001-5719-4617
Emanuela Callone″Klaus Müller″ Magnetic Resonance Lab., Department of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Carlos MotaDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Minderbroedersberg 4-6, 6211LK Maastricht, The Netherlands.ORCID 0000-0001-5935-6245
Antonella MottaDepartment of Industrial Engineering and BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0003-4893-6863
Devid ManiglioDepartment of Industrial Engineering and BIOtech Research Center, University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-1653-861X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extrusion-based bioprinting is one of the most widespread technologies due to its affordability, wide range of processable materials, and ease of use. However, the formulation of new inks for this technique is based on time-consuming trial-and-error processes to establish the optimal ink composition and printing parameters. Here, a dynamic printability window was modeled for the assessment of the printability of polysaccharide blend inks of alginate and hyaluronic acid with the intent to build a versatile predictive tool to speed up the testing procedures. The model considers both the rheological properties of the blends (viscosity, shear thinning behavior, and viscoelasticity) and their printability (in terms of extrudability and the ability of forming a well-defined filament and detailed geometries). By imposing some conditions on the model equations, it was possible to define empirical bands in which the printability is ensured. The predictive capability of the built model was successfully verified on an untested blend of alginate and hyaluronic acid chosen to simultaneously optimize the printability index and minimize the size of the deposited filament.

Indexed as

BioprintingInkAlginatesHyaluronic AcidPrinting, Three-DimensionalAlginatesHyaluronic Acidextrusion bioprintinghyaluronic acidprintabilitysodium alginate

Identifiers

PMID36848685
PMCPMC10015426

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.