Evidence map›Paper›PMID 36848578›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Multifaceted role for p53 in pancreatic cancer suppression.

Stephano S Mello, Brittany M Flowers, Pawel K Mazur, James J Lee, Fabian Müller, Sarah K Denny, Sofia Ferreira, Kathryn Hanson, Seung K Kim, William J Greenleaf and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  12. Signaling pathways and targeted interventions for precancers.Signal transduction and targeted therapy · 2026
    Review
  13. Novel Acinar Metaplastic States Uncovered in Exocrine Pancreas Disease.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Stephano S MelloDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2484-086X
Brittany M FlowersDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1030-306X
Pawel K MazurDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0002-5820-8344
James J LeeDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
Fabian MüllerDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-5809-2321
Sarah K DennyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Sofia FerreiraDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-9535-2161
Kathryn HansonDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-3528-0797
Seung K KimDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
William J GreenleafDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-1409-3095
Laura D WoodDepartment of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Laura D AttardiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-1782-9045
Stanford University · USEnzo Life Sciences (United States) · USJohns Hopkins University · USSaarland University · DEThe University of Texas MD Anderson Cancer Center · USUniversity of Rochester Medical Center · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Integrative approaches to elucidate p53 transcriptional networks during carcinogenesisR35CA197591 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI · 2015 to 2026
$11.6M
Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapyP01CA244114 · NCI · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2021 to 2025
$10.0M
Mouse Models to Dissect p53 Tumor Suppressor FunctionR01CA140875 · NCI · STANFORD UNIVERSITY · PI ATTARDI, LAURA D · 2011 to 2015
$1.7M
Elucidating p53 transcriptional networks involved in pancreatic cancer suppressioR21CA169673 · NCI · STANFORD UNIVERSITY · PI ATTARDI, LAURA D · 2012 to 2013
$368k
NCI NIH HHS P01 CA244114NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA140875NCI NIH HHS R21 CA169673NCI NIH HHS R35 CA197591
6 · The paper itself

Abstract

The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor

Indexed as

Pancreatic NeoplasmsPrecancerous ConditionsAnimalsAnophthalmosHumansLung DiseasesMetaplasiaMiceMice, KnockoutMicrophthalmosPancreasProto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53Proto-Oncogene Proteins p21(ras)Tumor Suppressor Protein p53ADMp53pancreatic cancerpancreatitisPanIN

Identifiers

PMID36848578
PMCPMC10013849
OpenAlexW4322421452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.