Evidence map›Paper›PMID 36848506›Full record

ArticleThe American naturalist2023

Host Phenology Can Select for Multiple Stable Parasite Virulence Strategies in Obligate Killer Parasites.

Hannelore MacDonald, Dustin Brisson

Abstract read
In one paragraph

Article in The American naturalist, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hannelore MacDonald
Dustin Brisson

Funding

PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
Training in Emerging Infectious DiseasesT32AI055400 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, HENSLEY, SCOTT ERIC · 2003 to 2022
$4.4M
Phylogeographic dynamics of tick-borne pathogensR01AI142572 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRISSON, DUSTIN · 2018 to 2023
$2.4M
Phylogeographic dynamics of a vector and pathogen in a natural environmentR01AI097137 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRISSON, DUSTIN · 2012 to 2016
$1.9M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
NIAID NIH HHS R01 AI097137NIAID NIH HHS R01 AI142572NIAID NIH HHS R01 AI164715NIAID NIH HHS T32 AI007532NIAID NIH HHS T32 AI055400
6 · The paper itself

Abstract

AbstractThe timing of seasonal host activity, or host phenology, is an important driver of parasite transmission dynamics and evolution. Despite the vast diversity of parasites in seasonal environments, the impact of phenology on parasite diversity remains relatively understudied. For example, little is known about the selective pressures and environmental conditions that favor a monocyclic strategy (complete a single cycle of infection per season) or a polycyclic strategy (complete multiple cycles). Here, we present a mathematical model that demonstrates that seasonal host activity patterns can generate evolutionary bistability in which two evolutionarily stable strategies (ESSs) are possible. The ESS that a particular system reaches is a function of the virulence strategy initially introduced into the system. The results demonstrate that host phenology can, in theory, maintain diverse parasite strategies among isolated geographic locations.

Indexed as

ParasitesAnimalsSeasonsVirulenceadaptationevolutionparasitephenology

Identifiers

PMID36848506
PMCPMC11003751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.