ArticleStroke2023
Impact of Time to Treatment on Endovascular Thrombectomy Outcomes in the Early Versus Late Treatment Time Windows.
Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Efficacy and Safety of Jiannao Tongluo Granules in the Treatment of Convalescent Cerebral Infarction: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.Current medical science · 2026Article
- Neighborhood economic and demographic landscape as predictors of 90-day outcomes post-stroke hospitalization.Frontiers in stroke · 2026Article
- Treatment time metrics and functional outcomes after endovascular thrombectomy in routine clinical practice.Frontiers in neurology · 2026Article
- Effects of Stroke Awareness on Onset-to-Hospital Time and Healthcare Costs in Acute Ischemic Stroke: A Cross-Sectional Study.Noro psikiyatri arsivi · 2026Article
- Stroke coordinators perceived roles, responsibilities, & resources: Florida Stroke Registry insights.International journal of nursing studies advances · 2025Article
- Procedure time and outcomes in acute ischemic stroke with anterior circulation large vessel occlusion in the early and late time windows: A stratified analysis by onset-to-puncture time.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Serially-Connected Soft Continuum Robots for Endovascular Emergencies.IEEE transactions on medical robotics and bionics · 2025Article
- Does endovascular thrombectomy using super-bore 0.088" large distal platform offer advantages over balloon guide catheters in acute ischemic stroke secondary to large vessel occlusion?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Article
- Association Between Premorbid Frailty Status and Functional Independence in Acute Ischemic Stroke Patients Following Endovascular Treatment in the Late Window.Clinical interventions in aging · 2025Article
- Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Review
- Delayed door to puncture time during off-duty hours is associated with unfavorable outcomes after mechanical thrombectomy in the early window of acute ischemic stroke.BMC neurology · 2024Article
- Predictors of In-Hospital Mortality after Thrombectomy in Anterior Circulation Large Vessel Occlusion: A Retrospective, Machine Learning Study.Diagnostics (Basel, Switzerland) · 2024Article
- Effect of left ventricular ejection fraction Spectrum on 1-Year mortality in patients with acute ischemic stroke or transient ischemic attack.CNS neuroscience & therapeutics · 2023Article
- The effect of intravenous thrombolysis on patients with successful thrombectomy depends on final reperfusion grade: A retrospective study.CNS neuroscience & therapeutics · 2023Article
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe impact of time to treatment on outcomes of endovascular thrombectomy (EVT) especially in patients presenting after 6 hours from symptom onset is not well characterized. We studied the differences in characteristics and treatment timelines of EVT-treated patients participating in the Florida Stroke Registry and aimed to characterize the extent to which time impacts EVT outcomes in the early and late time windows.
methodsProspectively collected data from Get With the Guidelines-Stroke hospitals participating in the Florida Stroke Registry from January 2010 to April 2020 were reviewed. Participants were EVT patients with onset-to-puncture time (OTP) of ≤24 hours and categorized into early window treated (OTP ≤6 hours) and late window treated (OTP >6 and ≤24 hours). Association between OTP and favorable discharge outcomes (independent ambulation, discharge home and to acute rehabilitation facility) as well as symptomatic intracerebral hemorrhage and in-hospital mortality were examined using multilevel-multivariable analysis with generalized estimating equations.
resultsAmong 8002 EVT patients (50.9% women; median age [±SD], 71.5 [±14.5] years; 61.7% White, 17.5% Black, and 21% Hispanic), 34.2% were treated in the late time window. Among all EVT patients, 32.4% were discharged home, 23.5% to rehabilitation facility, 33.7% ambulated independently at discharge, 5.1% had symptomatic intracerebral hemorrhage, and 9.2% died. As compared with the early window, treatment in the late window was associated with lower odds of independent ambulation (odds ratio [OR], 0.78 [0.67-0.90]) and discharge home (OR, 0.71 [0.63-0.80]). For every 60-minute increase in OTP, the odds of independent ambulation reduced by 8% (OR, 0.92 [0.87-0.97];
conclusionsIn routine practice, just over one-third of EVT-treated patients independently ambulate at discharge and only half are discharged to home/rehabilitation facility. Increased time from symptom onset to treatment is significantly associated with lower chance of independent ambulation and ability to be discharged home after EVT in the early time window.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.