Evidence map›Paper›PMID 36847926›Full record

ArticleJournal of the Egyptian National Cancer Institute2023

Studying ferroptosis and iron metabolism pre- and post-radiotherapy treatment in breast cancer patients.

Sanaa A El-Benhawy, Ibrahim G Abdelrhman, Nadia A Sadek, Enayat I Fahmy, Ahmed A AboGabal, Hossam Elmasry, Sally A M Saleh, Ola A Sakr, Mona Nagy Elwany, Maha Abubakr Feissal Rabie

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In one paragraph

Article in Journal of the Egyptian National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. AAT-MSC-EVs: Novel implications for suppressing ferroptosis, fibrosis and pain associated with chronic pancreatitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sanaa A El-BenhawyRadiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. sanaa.elbanhawi@alexu.edu.eg.
Ibrahim G AbdelrhmanRadiology and Medical Imaging Department, Faculty of Applied Health Sciences, October 6 University, Cairo, Egypt.
Nadia A SadekHematology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Enayat I FahmyRadiation Sciences Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Ahmed A AboGabalRadiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Hossam ElmasryMedical Laboratory Specialist, Baheya Foundation for Early Detection and Treatment of Breast Cancer, Cairo, Egypt.
Sally A M SalehHematology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Ola A SakrCancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Mona Nagy ElwanyPathology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Maha Abubakr Feissal RabieMedical Laboratory Department, Faculty of Applied Health Science Technology, Pharos University, Alexandria, Egypt.
Alexandria University · EGCairo University · EGOctober 6 University · EGPharos University in Alexandria · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiotherapy (RT) is an important part of the treatment of many tumors. Radiotherapy causes oxidative damage in all cellular compartments, including lipid membrane, on a random basis. Toxic lipid peroxidation accumulation has only lately been linked to a regulated type of cell death known as ferroptosis. Iron is required for ferroptosis sensitization in cells. AIM OF THE WORK: This work aimed to study ferroptosis and iron metabolism before and after RT in BC patients. SUBJECTS AND

methodsEighty participants were included divided into two main groups: group I: 40 BC patients treated with RT. Group II: 40 healthy volunteers' age and sex matched as control group. Venous blood samples were collected from BC patients (prior to and after RT) and healthy controls. Glutathione (GSH), malondialdehyde (MDA), serum iron levels and % of transferrin saturation were measured by colorimetric technique. Ferritin, ferroportin, and prostaglandin-endoperoxide synthase 2 (PTGS2) levels were assessed by ELISA.

resultsSerum ferroportin, reduced glutathione, and ferritin showed significant decrease after radiotherapy in comparison to before radiotherapy. However, there was significant increase in serum PTGS2, MDA, % of transferrin saturation and iron levels after radiotherapy in comparison to before radiotherapy.

conclusionRadiotherapy induced ferroptosis in breast cancer patients as a new cell death mechanism and PTGS2 is a biomarker of ferroptosis. Iron modulation is a useful approach for the treatment of BC especially if combined with targeted therapy and immune-based therapy. Further studies are warranted to be translated into clinical compounds.

Indexed as

Breast NeoplasmsFerroptosisCyclooxygenase 2FemaleFerritinsHumansTransferrinsCyclooxygenase 2FerritinsTransferrinsBreast cancerFerroptosisIron profileRadiotherapy

Identifiers

PMID36847926
PMCPMC13313956
OpenAlexW4322498349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.