Evidence map›Paper›PMID 36847872›Full record

Observational studyEuropean journal of pediatrics2023

Phototherapy and risk of developmental delay: the Japan Environment and Children's Study.

Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso and 1 more

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Masashi HottaDepartment of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.ORCID http://orcid.org/0000-0002-0867-8962
Kimiko UedaMaternal & Child Health Information Center, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.
Satoyo IkeharaDivision of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Kanami TanigawaMaternal & Child Health Information Center, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.
Hirofumi NakayamaOsaka Regional Center for Japan Environment and Children's Study (JECS), Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kazuko WadaDepartment of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.
Tadashi KimuraDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Keiichi OzonoDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tomotaka SobueDivision of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Hiroyasu IsoOsaka Regional Center for Japan Environment and Children's Study (JECS), Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan. iso@pbhel.med.osaka-u.ac.jp.
Japan Environment, Children’s Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This observational cohort study aimed to examine the association between the duration of phototherapy for neonatal jaundice and the risk of developmental delay at 3 years of age using nationwide birth cohort data. Data from 76,897 infants were analyzed. We divided participants into four groups: no phototherapy, short phototherapy (1-24 h), long phototherapy (25-48 h), and very long phototherapy (> 48 h). The Japanese version of the Ages and Stages Questionnaire-3 was used to evaluate the risk of developmental delay at 3 years of age. Logistic regression analysis was performed to assess the impact of phototherapy duration on the prevalence of developmental delay. After adjustment for potential risk factors, a dose-response relationship was identified between the duration of phototherapy and Ages and Stages Questionnaire-3, and the differences were significant in four domains; odds ratio for communication delay was associated with short, long, and very long phototherapy = 1.10 (95% confidence interval 0.97-1.26), 1.32 (1.04-2.66), and 1.48 (1.11-1.98), respectively; for gross motor delay = 1.01 (0.89-1.15), 1.28 (1.03-2.58), and 1.26 (0.96-1.67); for problem solving delay = 1.13 (1.03-1.25), 1.19 (0.99-1.43), and 1.41 (1.11-1.79); and for personal social delay = 1.15 (0.99-1.32), 1.10 (0.84-1.44), and 1.84 (1.38-2.45).

conclusionLonger duration of phototherapy is a predictive factor for developmental delay, making it important to avoid extended periods of phototherapy. However, whether it increases the prevalence of developmental delay remains unclear. WHAT IS KNOWN: • Phototherapy is a common treatment for neonatal jaundice, associated with both short-term and long-term complications. • However, an association between phototherapy and the prevalence of developmental delay has not been revealed in a large cohort study. WHAT IS NEW: • We identified that a long duration of phototherapy was a predictive factor for developmental delay at 3 years of age. • However, whether a long duration of phototherapy increases the prevalence of developmental delay remains unclear.

Indexed as

Jaundice, NeonatalChildChild DevelopmentCohort StudiesHumansInfantInfant, NewbornJapanPhototherapyBirth cohortInfantInfant developmentJaundiceNewbornPhototherapy

Identifiers

PMID36847872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.