Evidence map›Paper›PMID 36847849›Full record

ArticleCellular and molecular life sciences : CMLS2023

The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.

Shunqun Luo, Nurcin Liman, Can Li, Assiatu Crossman, Eddie C Y Wang, Françoise Meylan, Jung-Hyun Park

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shunqun Luo *Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Dr, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-5728-2112
Nurcin Liman *Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Dr, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-2910-1070
Can LiExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Dr, Bethesda, MD, 20892, USA.
Assiatu CrossmanExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Dr, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0001-5746-0073
Eddie C Y WangDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Françoise MeylanTranslational Immunology Section, NIAMS, NIH, Bethesda, MD, 20892, USA.
Jung-Hyun ParkExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Dr, Bethesda, MD, 20892, USA. Parkhy@mail.nih.gov.ORCID http://orcid.org/0000-0002-9547-9055
National Cancer Institute · USCardiff University · GBNational Institutes of Health · US

Funding

Application of Flow Cytometry to Cell BiologyZICBC009255 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CROSSMAN, ASSIATU · 2009 to 2025
$26.4M
Post-Transcriptional Regulation of Interleukin-7 Receptor ExpressionZIABC011214 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PARK, JUNG-HYUN · 2009 to 2025
$15.9M
Immune Regulatory Roles of Suppressor Of Cytokine Signaling (SOCS) MoleculesZIABC011215 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PARK, JUNG-HYUN · 2009 to 2025
$6.9M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011215Medical Research Council G0901119Medical Research Council MR/V000489/1
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells correspond to a population of thymus-generated T cells with innate-like characteristics and effector functions. Among the various iNKT subsets, NKT17 is the only subset that produces the proinflammatory cytokine IL-17. But, how NKT17 cells acquire this ability and what would selectively trigger their activation remain incompletely understood. Here, we identified the cytokine receptor DR3 being specifically expressed on thymic NKT17 cells and mostly absent on other thymic iNKT subsets. Moreover, DR3 ligation promoted the in vivo activation of thymic NKT17 cells and provided costimulatory effects upon agonistic α-GalCer stimulation. Thus, we identified a specific surface marker for thymic NKT17 cells that triggers their activation and augments their effector functions both in vivo and in vitro. These findings provide new insights for deciphering the role and function of murine NKT17 cells and for understanding the development and activation mechanisms of iNKT cells in general.

Indexed as

Natural Killer T-CellsReceptors, Tumor Necrosis Factor, Member 25Thymus GlandAnimalsCytokinesMiceReceptors, CytokineCytokinesReceptors, CytokineReceptors, Tumor Necrosis Factor, Member 25Tnfrsf25 protein, mouseCD138IL-17iNKT cellsRORγtThymus

Identifiers

PMID36847849
PMCPMC10838626
OpenAlexW4322493914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.