Evidence map›Paper›PMID 36847778›Full record

ArticleCancer research2023

Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma.

Tingting Liu, Juan Wang, Hongbo Yang, Qiushi Jin, Xiaotao Wang, Yihao Fu, Yu Luan, Qixuan Wang, Mark W Youngblood, Xinyan Lu and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  7. Three-dimensional genome architecture in intrahepatic cholangiocarcinoma.Cellular oncology (Dordrecht, Netherlands) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tingting Liu *Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0003-4118-016X
Juan Wang *Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0003-0933-3744
Hongbo YangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-5193-8838
Qiushi JinDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-6499-1910
Xiaotao WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-3531-2157
Yihao FuDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-4605-0973
Yu LuanDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0003-1778-9071
Qixuan WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0001-6612-3634
Mark W YoungbloodDepartment of Neurosurgery, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-1044-8015
Xinyan LuDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-4037-9284
Lucia CasadeiProgram in Translational Therapeutics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-5731-8197
Raphael PollockProgram in Translational Therapeutics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-0443-1583
Feng YueDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois.ORCID 0000-0002-7954-5462
Northwestern University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating CenterU24HG012070 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang, Feng Yue · 2021 to 2026
$9.7M
Impact of genetic variants on gene regulation and 3D genome organization in human diseasesR35GM124820 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Feng Yue · 2017 to 2026
$4.0M
Visualization, modeling and validation of chromatin interaction dataR01HG009906 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YUE, FENG · 2018 to 2022
$2.0M
Computational methods to identify neo-TADs and enhancer-hijacking in rearranged genomesR01HG011207 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YUE, FENG · 2021 to 2024
$1.6M
NCI NIH HHS P30 CA016058NHGRI NIH HHS R01 HG009906NHGRI NIH HHS R01 HG011207NHGRI NIH HHS U24 HG012070NIGMS NIH HHS R35 GM124820
6 · The paper itself

Abstract

significanceComprehensive profiling of the enhancer landscape and 3D genome structure in liposarcoma identifies extensive enhancer-oncogene coamplification and enhancer hijacking events, deepening the understanding of how oncogenes are regulated in cancer.

Indexed as

LiposarcomaOncogenesEnhancer Elements, GeneticHumans

Identifiers

PMID36847778
PMCPMC10152236
OpenAlexW4322492580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.