Evidence map›Paper›PMID 36847414›Full record

ArticleAutophagy2023

The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.

Nikoline L Rasmussen, Jianwen Zhou, Hallvard Olsvik, Stéphanie Kaeser-Pebernard, Trond Lamark, Joern Dengjel, Terje Johansen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Structural basis for TNIP1 binding to FIP200 during mitophagy.The Journal of biological chemistry · 2024
    Article
  2. Influence of CCancers · 2023
    Article
  3. Repressive Control of Keratinocyte Cytoplasmic Inflammatory Signaling.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nikoline L RasmussenAutophagy Research Group, Department of Medical Biology, University of Tromsø - the Arctic University of Norway, Tromsø, Norway.ORCID 0000-0002-9823-7326
Jianwen ZhouDepartment of Biology, University of Fribourg, Fribourg, Freiburg, Switzerland.ORCID 0000-0001-6729-1154
Hallvard OlsvikAutophagy Research Group, Department of Medical Biology, University of Tromsø - the Arctic University of Norway, Tromsø, Norway.
Stéphanie Kaeser-PebernardDepartment of Biology, University of Fribourg, Fribourg, Freiburg, Switzerland.ORCID 0000-0002-6035-6979
Trond LamarkAutophagy Research Group, Department of Medical Biology, University of Tromsø - the Arctic University of Norway, Tromsø, Norway.
Joern DengjelDepartment of Biology, University of Fribourg, Fribourg, Freiburg, Switzerland.ORCID 0000-0002-9453-4614
Terje JohansenAutophagy Research Group, Department of Medical Biology, University of Tromsø - the Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-1451-9578
UiT The Arctic University of Norway · NOUniversity of Fribourg · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inflammatory repressor TNIP1/ABIN-1 is important for keeping in check inflammatory and cell-death pathways to avoid potentially dangerous sustained activation of these pathways. We have now found that TNIP1 is rapidly degraded by selective macroautophagy/autophagy early (0-4 h) after activation of TLR3 by poly(I:C)-treatment to allow expression of pro-inflammatory genes and proteins. A few hours later (6 h), TNIP1 levels rise again to counteract sustained inflammatory signaling. TBK1-mediated phosphorylation of a TNIP1 LIR motif regulates selective autophagy of TNIP1 by stimulating interaction with Atg8-family proteins. This is a novel level of regulation of TNIP1, whose protein level is crucial for controlling inflammatory signaling.

Indexed as

AutophagyDNA-Binding ProteinsMicrotubule-Associated ProteinsAmino Acid MotifsAutophagy-Related Protein 8 FamilyHumansPhosphorylationTranscription FactorsAutophagy-Related Protein 8 FamilyDNA-Binding ProteinsMicrotubule-Associated ProteinsTNIP1 protein, humanTranscription FactorsABIN-1Atg8autophagyinflammationLIRTBK1TNIP1

Identifiers

PMID36847414
PMCPMC10472839
OpenAlexW4322494579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.