ArticleEpidemiology and psychiatric sciences2023
Alcohol use as a predictor of the course of major depressive disorder: a prospective population-based study.
Article in Epidemiology and psychiatric sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.European archives of psychiatry and clinical neuroscience · 2026Review
- Reciprocal longitudinal relationship between depressive symptoms and problematic alcohol use: a random intercept cross-lagged panel model including a nationwide sample of Korean adults.European archives of psychiatry and clinical neuroscience · 2026Article
- Early Trajectory of Depressive Symptoms in Alcohol Dependence: Insights From a Four-Week Clinical Decision Window.Cureus · 2026Article
- Passive data do not improve prediction or detection of alcohol consumption beyond temporal patterns in major depression: A 90-day cross-validated study.Addictive behaviors · 2026Article
- Alcohol Consumption and Depressive Symptoms in Romanian University Students: Post-Pandemic Insights from a Non-Clinical Cohort.Journal of clinical medicine · 2026Article
- Epidemiology of alcohol use in Sri Lanka: Findings of the SLHAS national survey.Global epidemiology · 2025Article
- Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review.Alcohol, clinical & experimental research · 2025Review
- The impact of psychiatric comorbidities associated with depression: a literature review.Medicine and pharmacy reports · 2024Review
- Identifying the subgroups of depression trajectories among the middle-aged and older Chinese individuals with chronic diseases: an 8-year follow-up study based on CHARLS.Frontiers in public health · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
aimsThere are indications that problematic alcohol use may negatively impact the course of major depressive disorder (MDD). However, most studies on alcohol use and adverse MDD outcomes are conducted amongst MDD populations with (severe) alcohol use disorder in psychiatric treatment settings. Therefore, it remains unclear whether these results can be generalised to the general population. In light of this, we examined the longitudinal relationship between alcohol use and MDD persistence after a 3-year follow-up amongst people with MDD from the general population.
methodsData were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a psychiatric epidemiological prospective study comprising four waves amongst the adult Dutch general population (
resultsThe majority (67.4%) of the MDD sample were female, while the mean age was 47.1 years. Amongst these, 23.8% were non-drinkers, 52.0% were low-risk drinkers and 14.3% and 9.4% were at-risk and high-risk drinkers, respectively. Around one-quarter of the sample (23.6%) met the criteria for a persistent MDD after 3-year follow-up. No statistically significant association was found between alcohol use and MDD persistence, either for the crude model or the adjusted models. In comparison to low-risk drinking, the full adjusted model showed no statistically significant associations between MDD persistence and non-drinking (odds ratio (OR) = 1.15,
conclusionsContrary to our expectations, our findings showed that alcohol use was not a predictor of MDD persistence after 3-year follow-up amongst people with MDD from the general population.
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