ArticleAging cell2023
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.
Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models.BMC neuroscience · 2025Pooled it
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- MRI of Syrian hamsters reveals SARS-CoV-2 variant-specific neuroinflammation.Microbiology spectrum · 2026Article
- Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies.Frontiers in aging neuroscience · 2026Review
- Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026Review
- Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.Journal of Huntington's disease · 2025Review
- Emerging strategies, applications and challenges of targeting NADNature aging · 2025Review
- Analysis of the current state of frailty indexes and their implementation for aging intervention studies.Aging · 2025Review
- Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism.Journal of advanced research · 2025Article
- Senolytic effects of a modified Gingerenone A.npj aging · 2025Article
- Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review.Cellular and molecular life sciences : CMLS · 2025Review
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.Aging cell · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory dysfunction is a prevalent symptom and an early marker of age-related neurodegenerative diseases in humans, including Alzheimer's and Parkinson's Diseases. However, as olfactory dysfunction is also a common symptom of normal aging, it is important to identify associated behavioral and mechanistic changes that underlie olfactory dysfunction in nonpathological aging. In the present study, we systematically investigated age-related behavioral changes in four specific domains of olfaction and the molecular basis in C57BL/6J mice. Our results showed that selective loss of odor discrimination was the earliest smelling behavioral change with aging, followed by a decline in odor sensitivity and detection while odor habituation remained in old mice. Compared to behavioral changes related with cognitive and motor functions, smelling loss was among the earliest biomarkers of aging. During aging, metabolites related with oxidative stress, osmolytes, and infection became dysregulated in the olfactory bulb, and G protein coupled receptor-related signaling was significantly down regulated in olfactory bulbs of aged mice. Poly ADP-ribosylation levels, protein expression of DNA damage markers, and inflammation increased significantly in the olfactory bulb of older mice. Lower NAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.