Evidence map›Paper›PMID 36846717›Full record

ArticleOxidative medicine and cellular longevity2023

Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway.

Longfei Xiao, Zihao Fang, Qian Wang, Xihui Sheng, Xiaolong Qi, Kai Xing, Yong Guo, Hemin Ni, Xiangguo Wang, Yong Zhang

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Frontiers in cellular and infection microbiology · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Longfei XiaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.ORCID https://orcid.org/0000-0001-5790-6645
Zihao FangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Qian WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Xihui ShengAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Xiaolong QiAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Kai XingAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Yong GuoAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Hemin NiAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.
Xiangguo WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, China.ORCID https://orcid.org/0000-0002-5001-7930
Yong ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.ORCID https://orcid.org/0000-0002-5249-7595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood-testis barrier (BTB) made of concomitant junction apparatus between Sertoli cells (SCs) is crucial for spermatogenesis. The tight junction (TJ) function is impaired in SCs with age, exhibiting an intimate relationship to testicular dysfunction induced by age. In this study, compared with those in young boars, TJ proteins (i.e., Occludin, ZO-1, and plus Claudin-11) were discovered to have reduced expressions in testes, and spermatogenesis ability declined in old boars. An

Indexed as

CurcuminSirtuin 3AMP-Activated Protein KinasesAnimalsClaudinsInflammasomesMaleMiceNLR Family, Pyrin Domain-Containing 3 ProteinOccludinSertoli CellsSignal TransductionSwineTight Junction ProteinsTight JunctionsAMP-Activated Protein KinasesClaudinsCurcuminInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOccludinSirt3 protein, mouseSirtuin 3Tight Junction Proteins

Identifiers

PMID36846717
PMCPMC9957632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.