Evidence map›Paper›PMID 36846611›Full record

ArticleOpen forum infectious diseases2023

Factors Associated With Long COVID Symptoms in an Online Cohort Study.

Matthew S Durstenfeld, Michael J Peluso, Noah D Peyser, Feng Lin, Sara J Knight, Audrey Djibo, Rasha Khatib, Heather Kitzman, Emily O'Brien, Natasha Williams and 7 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Understanding how social determinants of health shape Long COVID outcomes: a rapid review of evidence.Archives of public health = Archives belges de sante publique · 2025
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  18. Long Covid Symptom Clusters, Correlates and Predictors in a Highly Vaccinated Australian Population in 2023.Health expectations : an international journal of public participation in health care and health policy · 2025
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Matthew S DurstenfeldDivision of Cardiology at ZSFG, and Department of Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7612-3352
Michael J PelusoDivision of HIV, Infectious Disease, Global Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-0585-6230
Noah D PeyserDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Feng LinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Sara J KnightDivision of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Audrey DjiboCVS Health Clinical Trial Services, Blue Bell, Pennsylvania, USA.
Rasha KhatibAdvocate Aurora Research Institute, Milwaukee, Wisconsin, USA.
Heather KitzmanBaylor Scott and White Health and Wellness Center, Dallas, Texas, USA.
Emily O'BrienDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Natasha WilliamsInstitute for Excellence in Health Equity, Center for Healthful Behavior Change, NYU Grossman School of Medicine, New York, New York, USA.
Carmen IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID https://orcid.org/0000-0003-2700-9593
John KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Thomas W CartonLouisiana Public Health Institute, New Orleans, Louisiana, USA.
Jeffrey E OlginDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Mark J PletcherDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Gregory M MarcusDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Alexis L BeattyDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USAlbert Einstein College of Medicine · USBaylor Scott & White Health · USCVS Health (United States) · USDuke University · USLouisiana Public Health Institute · USUniversity of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
The Health ePeople Resource for Mobilized ResearchU2CEB021881 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCUS, GREGORY M, OLGIN, JEFFREY E · 2015 to 2020
$10.3M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
Characterizing the virologic and immunologic signatures of HIV exceptional controlK23AI157875 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PELUSO, MICHAEL JOSEPH · 2021 to 2025
$927k
Gates Foundation INV-017206NCATS NIH HHS UL1 TR002538NHLBI NIH HHS K12 HL143961NIAID NIH HHS K23 AI157875NIAID NIH HHS L30 AI147159NIBIB NIH HHS U2C EB021881
6 · The paper itself

Abstract

Background: Few prospective studies of Long COVID risk factors have been conducted. The purpose of this study was to determine whether sociodemographic factors, lifestyle, or medical history preceding COVID-19 or characteristics of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are associated with Long COVID. Methods: In March 26, 2020, the COVID-19 Citizen Science study, an online cohort study, began enrolling participants with longitudinal assessment of symptoms before, during, and after SARS-CoV-2 infection. Adult participants who reported a positive SARS-CoV-2 test result before April 4, 2022 were surveyed for Long COVID symptoms. The primary outcome was at least 1 prevalent Long COVID symptom greater than 1 month after acute infection. Exposures of interest included age, sex, race/ethnicity, education, employment, socioeconomic status/financial insecurity, self-reported medical history, vaccination status, variant wave, number of acute symptoms, pre-COVID depression, anxiety, alcohol and drug use, sleep, and exercise. Results: Of 13 305 participants who reported a SARS-CoV-2 positive test, 1480 (11.1%) responded. Respondents' mean age was 53 and 1017 (69%) were female. Four hundred seventy-six (32.2%) participants reported Long COVID symptoms at a median 360 days after infection. In multivariable models, number of acute symptoms (odds ratio [OR], 1.30 per symptom; 95% confidence interval [CI], 1.20-1.40), lower socioeconomic status/financial insecurity (OR, 1.62; 95% CI, 1.02-2.63), preinfection depression (OR, 1.08; 95% CI, 1.01-1.16), and earlier variants (OR = 0.37 for Omicron compared with ancestral strain; 95% CI, 0.15-0.90) were associated with Long COVID symptoms. Conclusions: Variant wave, severity of acute infection, lower socioeconomic status, and pre-existing depression are associated with Long COVID symptoms.

Indexed as

COVID-19long COVIDpatient-reported outcomesPost-Acute Sequelae of SARS-CoV-2 (PASC)SARS-CoV-2

Identifiers

PMID36846611
PMCPMC9945931
OpenAlexW4318825489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.