Evidence map›Paper›PMID 36846564›Full record

ArticleDermatology research and practice2023

Dupilumab: Direct Cost and Clinical Evaluation in Patients with Atopic Dermatitis.

Marco Ferrari, Matthew G Donadu, Gabriele Biondi, Laura Saderi, Federica Sucato, Maria A Montesu, Paola Ruggiu, Paola Merella, Carla Chessa, Angela Sias and 4 more

Abstract read
In one paragraph

Article in Dermatology research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. How to Understand Personalized Medicine in Atopic Dermatitis Nowadays?International journal of molecular sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marco FerrariDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID https://orcid.org/0000-0001-7331-0032
Matthew G DonaduDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID https://orcid.org/0000-0001-7681-6194
Gabriele BiondiDepartment of Clinical and Experimental Medicine, Dermatology Unit, University of Sassari, Sassari, Italy.ORCID https://orcid.org/0000-0003-0507-0633
Laura SaderiClinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Federica SucatoDepartment of Clinical and Experimental Medicine, Dermatology Unit, University of Sassari, Sassari, Italy.
Maria A MontesuDepartment of Clinical and Experimental Medicine, Dermatology Unit, University of Sassari, Sassari, Italy.
Paola RuggiuHospital Pharmacy, Sassari University Hospital, Sassari, Italy.
Paola MerellaHospital Pharmacy, Sassari University Hospital, Sassari, Italy.
Carla ChessaHospital Pharmacy, Sassari University Hospital, Sassari, Italy.
Angela SiasHospital Pharmacy, Sassari University Hospital, Sassari, Italy.
Gabriella CarmelitaHospital Pharmacy, Sassari University Hospital, Sassari, Italy.
Vittorio MazzarelloDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Satta RosannaDepartment of Clinical and Experimental Medicine, Dermatology Unit, University of Sassari, Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Health care spending in Italy is high and continues to increase; assessing the long-term health and economic outcomes of new therapies is essential. Atopic dermatitis (AD) is a chronic, pruritic, immune-mediated inflammatory dermatosis, a clinical condition that significantly affects patients' quality of life at a high cost and requires continuous care. This retrospective study aimed to assess the direct cost and adverse drug reactions (ADRs) of Dupilumab and patients' clinical outcomes. All AD patients treated with Dupilumab at the Sassari University Hospital, Italy, between January 2019 and December 2021 were included. Eczema Area Severity Index, Dermatology Life Quality Index, and Itch Numeric Rating Scale scores were measured. ADRs and drug expenses were analyzed. A statistically significant posttreatment improvement was observed for all the indices measured: EASI (

Identifiers

PMID36846564
PMCPMC9946764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.