ArticleFrontiers in cellular and infection microbiology2022
Selective depletion of regulatory T cells enhances the immunogenicity of a recombinant-based vaccine against
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combining disciplines in the field of modern microbiology: a quantitative analysis of the literature on sporotrichosis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Article
- Aging and vaccines: impact of immunosenescence and inflammaging in vaccine response.Frontiers in aging · 2026Review
- Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice.Frontiers in immunology · 2026Article
- Integrating Cellular Immune Biomarkers with Machine Learning to Identify Potential Correlates of Protection for aVaccines · 2025Article
- Vaccine development for pathogenic fungi: current status and future directions.Expert review of vaccinesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Regulatory T cells (Tregs) have been shown to limit the protective immune response against pathogenic species of the fungus Methods: We evaluated the effect of Tregs depletion on the immunogenicity of an experimental recombinant anti- Results: Tregs depletion enhanced the frequency of specific IFNγ+ T cells (Th1 lymphocytes) and cytokine production after either the first or second vaccine dose. However, depletion of Tregs during the second dose caused greater stimulation of specific Th1 lymphocytes than depletion during the first dose. Similarly, the highest production of IgG, IgG1, and IgG2a anti rSsEno antibody was detected after Tregs depletion during boost immunization compared to the other immunized groups. Importantly, vaccine immunogenicity improvement after Tregs depletion also had an impact on the more efficient reduction of fungal load in the skin and liver after the challenge with Discussion: Our results illustrate that Tregs restrict vaccine-induced immune response and their transient depletion could enhance anti-
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Registered trials
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