ArticleOTA international : the open access journal of orthopaedic trauma2023
Local administration of vancomycin powder in orthopaedic fracture surgery: current practice and trends.
Article in OTA international : the open access journal of orthopaedic trauma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intrawound vancomycin powder for infection prophylaxis in definitive fixation of complex fractures: a systematic review and meta-analysis of efficacy and safety.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Pooled it
- Does topical vancomycin prevent fracture-related infections in closed fractures undergoing open reduction and internal fixation? A randomised controlled trial.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Trial
- Reported practice patterns in the use of local antibiotics for fracture-related infection among SICOT respondents: an international survey.BMC musculoskeletal disorders · 2026Article
- Review
- Use of intraoperative vancomycin powder and its effects on the incidence of surgical site infection in orthopaedic trauma: a systematic review with meta-analysis.OTA international : the open access journal of orthopaedic trauma · 2026Article
- The Role of Intrawound Vancomycin Powder in Reducing Surgical Site Infections in Orthopedic Surgery: A Comprehensive Narrative Review of Its Efficacy, Safety, and Applications.Indian journal of orthopaedics · 2025Review
- Formulation and Characterization of Bone-Targeting Vancomycin-Loaded Liposomes.Pharmaceutics · 2025Article
- Outcomes Associated with Choice of Prophylactic Antibiotics in Open Fractures.The Journal of bone and joint surgery. American volume · 2025Article
- Post-operative infection following ankle fracture surgery: a current concepts review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Risk Factors and Complications in Tibiotalocalcaneal (TTC) Arthrodesis: A Nationwide Database Comparison Between Traumatic Ankle Fracture and Osteoarthritis.Foot & ankle orthopaedics · 2025Article
- Article
- The antibiotic bead pouch - a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery.Journal of bone and joint infection · 2023Review
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Surgical site infections in orthopaedic trauma are a significant problem with meaningful patient and health care system-level consequences. Direct application of antibiotics to the surgical field has many potential benefits in reducing surgical site infections. However, to date, the data regarding the local administration of antibiotics have been mixed. This study reports on the variability of prophylactic vancomycin powder use in orthopaedic trauma cases across 28 centers. Methods: Intrawound topical antibiotic powder use was prospectively collected within three multicenter fracture fixation trials. Fracture location, Gustilo classification, recruiting center, and surgeon information were collected. Differences in practice patterns across recruiting center and injury characteristics were tested using chi-square statistic and logistic regression. Additional stratified analyses by recruiting center and individual surgeon were performed. Results: A total of 4941 fractures were treated, and vancomycin powder was used in 1547 patients (31%) overall. Local administration of vancomycin powder was more frequent in open fractures 38.8% (738/1901) compared with closed fractures 26.6% (809/3040) ( Conclusions: Prophylactic intrawound vancomycin powder remains controversial with varied support throughout the literature. This study demonstrates wide variability in its use across institutions, fracture types, and surgeons. This study highlights the opportunity for increased practice standardization for infection prophylaxis interventions. Level of Evidence: Prognostic-III.
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