ArticleFrontiers in psychiatry2023
Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005-2018 analyses.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Inflammatory and Cardiovascular Responses to Active and Passive Acute Psychological Stress.Biopsychosocial science and medicineTrial
- Systemic inflammation and mental health: A J-shaped dose-response pattern in depression based on NHANES 2005 to 2018.Medicine · 2026Article
- Associations Between Major Depressive Disorder, Multimorbidity Burden, and Inflammatory Biomarkers (NLR, PLR, MLR, SII, and MHR) in a Primary Care Population.Journal of clinical medicine · 2026Article
- Smoking and depressive symptoms: the mediating role of systemic inflammation in a US nationally representative sample.Annals of general psychiatry · 2026Article
- Altered NK cell receptor profiles and immune-inflammatory markers in adolescent major depressive disorder: associations with cognitive impairment.BMC psychiatry · 2026Article
- Factors associated with depression among people with cancer: Systematic umbrella review.Palliative & supportive care · 2026Review
- Association Between C-Reactive Protein-Triglyceride Glucose Index and Depressive Symptoms Among US Adults: A Nationally Representative Cross-Sectional Study From 2005 to 2023.Actas espanolas de psiquiatria · 2026Article
- Association of Systemic Inflammation Response Index With All-Cause and Cardiovascular Mortality Among Individuals With Depression: NHANES 2005-2018.Brain and behavior · 2026Article
- Article
- The relationship between suicidal behavior and hematological inflammatory parameters: a retrospective cohort study.Frontiers in psychiatry · 2026Article
- The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Aspirin use and risk of depression: a cross-sectional study.Frontiers in pharmacology · 2026Article
- Association between female HPV infection, inflammatory markers and depression: a cross-sectional and mediation analysis.BMC infectious diseases · 2025Article
- Evaluation of Systemic Inflammatory Indices of Earthquake Victims After the 6 February Kahramanmaraş Earthquake.Thoracic research and practice · 2025Article
- Systemic inflammatory indices and the risk of depression in individuals with sleep difficulties: A cohort study based on NHANES 2005-2020.Comprehensive psychoneuroendocrinology · 2025Article
- The systemic immune-inflammation index (SII) as a biomarker for depression in a community sample of adolescents.Comprehensive psychoneuroendocrinology · 2025Article
- Possible Association Between Concomitant Use of SSRIs with NSAIDs and an Increased Risk of Adverse Events Among People with Depressive Disorders: Data Mining of FDA Adverse Event Reporting System.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Systemic immune-inflammatory index mediates the association between regular walking and depression in the elderly with coronary heart disease.BMC geriatrics · 2025Article
- Oral Rehabilitation and Mental Health: Effects of the Renew Procedure on Depression Scores.Cureus · 2025Article
- Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study.BMC psychiatry · 2025Article
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4 authors.
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Abstract
Background/Aim: Depression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response. Methods: Based on the data of the National Health and Nutrition Examination Survey (NHANES), this study included 2,514 depressive and 26,487 non-depressive adults. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were used to quantify systemic inflammation. The multivariate logistic regression and inverse probability weighting methods were used to analyze the effect size of SII and SIRI on the risk of depression. Results: After adjusting for all confounders, the above associations of SII and SIRI with depression risk remained significant (SII, OR = 1.02, 95% CI = 1.01 to 1.02, Conclusion: Systemic inflammatory biomarkers (SII and SIRI) significantly affected the risk of depression. SII or SIRI can serve as a biomarker of anti-inflammation treatment for depression.
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