ArticleMediators of inflammation2023
Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study.
Article in Mediators of inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases.Frontiers in neurology · 2024Pooled it
- AI-Based Phenotyping of Atrial Fibrillation Through Generative Topographic Mapping: Prospective Murcia Atrial Fibrillation Project III Cohort Study.Journal of medical Internet research · 2026Observational
- Triglyceride-glucose indices distinguish clinical from preclinical obesity in US adults: A cross-sectional study.Medicine · 2026Article
- Atherogenic Index of Plasma and Residual Risk in Anticoagulated Patients With Atrial Fibrillation: The Prospective Murcia Atrial Fibrillation Project III Cohort.Journal of the American Heart Association · 2026Article
- Fasting blood glucose trajectories and atherosclerosis risk: a longitudinal cohort study with threshold analysis in Chongqing, China.Journal of health, population, and nutrition · 2026Article
- Predictive value of optic nerve sheath diameters on cerebral performance category scale in patients with impaired consciousness in the emergency department: a prospective pilot study.International journal of emergency medicine · 2026Article
- A machine learning model based on routine blood-derived indices for early arterial stiffness prediction in the community.Lipids in health and disease · 2026Article
- Insulin-resistance indices and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome stage 2: a comparative analysis of eGDR, TyG and METS-IR.Diabetology & metabolic syndrome · 2026Article
- Smoking-driven systemic inflammation elevates mortality risk in hypertensive patients: A cross-sectional study using insights from NHANES 1999-2018.Tobacco induced diseases · 2026Article
- The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.International journal of general medicine · 2026Article
- Association of TyG index with sepsis incidence and mortality: a prospective study with diabetes stratification.Frontiers in endocrinology · 2026Article
- Analyzing the association of estimated pulse wave velocity with the risk and mortality of chronic kidney disease: a study based on the NHANES database.International urology and nephrology · 2026Article
- High-fat diet, triglyceride glucose index, and gastrointestinal cancer: integrative insights from human and animal studies.Frontiers in nutrition · 2026Article
- Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank.Cardiovascular diabetology · 2025Article
- Article
- Association of the atherogenic index of plasma with the risk of cardiovascular disease and death among diabetic or prediabetic adults.Endocrine · 2025Article
- Identification of plasma phosphatidylethanolamine species associated with myocardial infarction risk in patients with stable angina: A cross-sectional lipidomics study.The Journal of international medical research · 2025Article
- Exploring the Systemic Immune-Inflammation Index as a novel biomarker for nonalcoholic fatty liver disease: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Investigating the relationship between blood factors and HDL-C levels in the bloodstream using machine learning methods.Journal of health, population, and nutrition · 2025Article
- Relationship between the atherogenic index of plasma and arthritis in American adults: Findings from the National Health and Nutrition Examination Survey 2005-2018.The Journal of international medical research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the U.S. general population, there is a lack of understanding regarding the association between the systemic immune inflammation (SII) index and estimated pulse wave velocity (ePWV), atherogenic index of plasma (AIP), and triglyceride-glucose (TyG) index and cardiovascular disease (CVD). As a result, the objective of our research was to investigate the association between the SII index and ePWV, AIP, and TyG index and incident CVD. We used the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 to conduct this study. The correlation between the SII index and ePWV, AIP, and TyG index was examined using generalized additive models with smooth functions. In addition, the association between SII index and triglyceride (TC), high-density lipoprotein cholesterol (HDL-C), and fast glucose (FBG) also were explored. Finally, we further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis to study the connection between the SII index and CVD. Our analysis included 17389 subjects from the NHANES database. A substantial positive association existed between SII, WV, and the TyG index. In addition, with the increase of the SII index, AIP showed a trend of decreasing first, then rising, and then decreasing. The SII index was inversely and linearly associated with triglyceride (TG), while positively and linearly associated with fast glucose (FBG). However, high-density lipoprotein cholesterol (HDL-C) had a tendency of first declining, then climbing, and finally falling with the rise in the SII index. After adjusting for potential confounders, compared with the lowest quartiles, the odds ratios with 95% confidence intervals for CVD across the quartiles were 0.914 (0.777, 1.074), 0.935 (0.779, 1.096), and 1.112 (0.956, 1.293) for SII index. The RCS plot showed an inverse U-shaped curve relationship between the SII index and CVD. Overall, this study found a strong correlation between a higher SII index and ePWV and the TyG index. Additionally, these cross-sectional data also revealed a U-shaped connection between the SII index and CVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.