Evidence map›Paper›PMID 36846134›Full record

ArticleFrontiers in neurology2023

Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [

Chao Zheng, Takuya Toyonaga, Baosheng Chen, LaShae Nicholson, William Mennie, Michael Liu, Joshua Spurrier, Kristin Deluca, Stephen M Strittmatter, Richard E Carson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Noninvasive Quantification of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Chao ZhengDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Baosheng ChenDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
LaShae NicholsonProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Departments of Neuroscience and Neurology, Yale University School of Medicine, New Haven, CT, United States.
William MennieDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Michael LiuDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Joshua SpurrierProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Departments of Neuroscience and Neurology, Yale University School of Medicine, New Haven, CT, United States.
Kristin DelucaProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Departments of Neuroscience and Neurology, Yale University School of Medicine, New Haven, CT, United States.
Stephen M StrittmatterProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Departments of Neuroscience and Neurology, Yale University School of Medicine, New Haven, CT, United States.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Zhengxin CaiDepartment of Radiology and Biomedical Imaging, PET Center, Yale School of Medicine, New Haven, CT, United States.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER, CHRISTOPHER H VAN DYCK · 2020 to 2026
$30.2M
Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Overlapping Molecular Dysregulation of Endolysosomal Function in Alzheimer's Disease and FTLD-TDPR01AG066165 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2019 to 2023
$3.9M
SV2A PET in Spinal Cord Injury ImagingR01NS123183 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai · 2022 to 2026
$3.3M
Development of PET imaging probes for ROCK2R01AG069921 · NIA · YALE UNIVERSITY · PI CAI, ZHENGXIN · 2021 to 2023
$2.5M
Development of Novel SV2A PET Agents for Early Detection of Alzheimers DiseaseR01AG058773 · NIA · YALE UNIVERSITY · PI CAI, ZHENGXIN · 2018 to 2020
$2.4M
Synaptic selectivity for microglial-mediated damage in Alzheimer's DiseaseRF1AG070926 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2021 to 2021
$2.4M
NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG034924NIA NIH HHS R01 AG058773NIA NIH HHS R01 AG066165NIA NIH HHS R01 AG069921NIA NIH HHS RF1 AG070926NINDS NIH HHS R01 NS123183
6 · The paper itself

Abstract

Introduction: Synapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [ Methods: Based on previous preclinical PET imaging studies using [ Results: To simplify and streamline the quantitative analysis, we compared the standardized uptake value ratios (SUVRs) from different imaging windows to DVRs and found that the averaged SUVRs from 60-90 min post-injection ( Conclusions: In conclusion, [

Indexed as

[18F]SDM-16APP/PS1brainDVRPETSRTMSUVRSV2A

Identifiers

PMID36846134
PMCPMC9945093
OpenAlexW4319602323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.