ArticleTransplantation direct2023
Ex Vivo Heart Perfusion for Cardiac Transplantation Allowing for Prolonged Perfusion Time and Extension of Distance Traveled for Procurement of Donor Hearts: An Initial Experience in the United States.
Article in Transplantation direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Conventional Cardiac Surgery in Donation After Circulatory Death Heart Transplantation: A United Network for Organ Sharing Registry Analysis.Clinical transplantation · 2026Article
- Optimizing recovery of marginal donor hearts with low ejection fraction: A national retrospective study from Switzerland.JHLT open · 2026Article
- Review
- Predictors of intraoperative donor heart turndown after initial acceptance for transplantation.JTCVS open · 2025Article
- Heart donation and transplant recipient survival outcomes from deceased organ donors managed in hospital-based vs independent donor care units.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Bridging to orthotopic heart transplant: Reducing the risk of intra-operative blood loss.JHLT open · 2025Article
- Donor Selection for Heart Transplantation in 2025.JACC. Heart failure · 2025Review
- Clinical Outcomes of Machine Perfusion and Temperature Control Systems in Heart Transplantation: Where We Stand.Journal of clinical medicine · 2025Review
- Severe primary graft failure: Are there lasting impacts? Analysis from the PHTS Database.JHLT open · 2025Article
- Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment.Journal of visualized experiments : JoVE · 2024Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scarcity of donor hearts continues to be a challenge for heart transplantation (HT). The recently Food and Drug Administration-approved Organ Care System (OCS; Heart, TransMedics) for ex vivo organ perfusion enables extension of ex situ intervals and thus may expand the donor pool. Because postapproval real-world outcomes of OCS in HT are lacking, we report our initial experience. Methods: We retrospectively reviewed consecutive patients who received HT at our institution in the post-Food and Drug Administration approval period from May 1 to October 15, 2022. Patients were divided into 2 groups: OCS versus conventional technique. Baseline characteristics and outcomes were compared. Results: A total of 21 patients received HT during this period, 8 using OCS and 13 conventional techniques. All hearts were from donation after brain death donors. The indication for OCS was an expected ischemic time of >4 h. Baseline characteristics in the 2 groups were comparable. The mean distance traveled for heart recovery was significantly higher in the OCS group (OCS, 845 ± 337, versus conventional, 186 ± 188 mi; Conclusions: OCS allowed utilization of donors from extended distances that otherwise would not be considered because ischemic time would be prohibitive by conventional technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.