Evidence map›Paper›PMID 36845659›Full record

ArticleFrontiers in aging neuroscience2023

Association of

Jingru Ren, Gaiyan Zhou, Yajie Wang, Ronggui Zhang, Zhiying Guo, Hao Zhou, Huifen Zheng, Yu Sun, Changyan Ma, Ming Lu and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451419 (Prospective and Controlled Glucocerebrosidase-related Parkinson's Disease Evaluation of Non Motor Symptoms), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06451419 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Prospective and Controlled Glucocerebrosidase-related Parkinson's Disease Evaluation of Non Motor Symptoms (PROGENS-PD)

TypeobservationalSponsorJuan Pablo Romero. MD, PhDRan2024 to 2026Enrolled40ConditionsParkinson DiseaseArmsTests on non motor symptoms
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Brain-muscle axis regulation of neuroinflammation and sarcopenia in Parkinson's disease: the bridging role of lactylation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Article
  3. Article
  4. Cortical and subcortical morphological alterations inFrontiers in aging neuroscience · 2026
    Article
  5. Genetic Modifiers of Parkinson's Disease: A Case-Control Study.Annals of clinical and translational neurology · 2025
    Observational
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingru RenDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Gaiyan ZhouDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yajie WangDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Ronggui ZhangDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Zhiying GuoDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Hao ZhouDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Huifen ZhengDepartment of Neurology, Geriatric Hospital of Nanjing Medical University, Nanjing, China.
Yu SunInternational Laboratory for Children's Medical Imaging Research, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China.
Changyan MaDepartment of Medical Genetics, Nanjing Medical University, Nanjing, China.
Ming LuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Weiguo LiuDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Variants in the glucocerebrosidase ( Methods: The entire Results: The estimated (standard error, SE) UPDRS motor [2.25 (0.38) points/year] and MoCA [-0.53 (0.11) points/year] progression rates in the Conclusion:

Indexed as

cognitive declineGBAlongitudinalmotor impairmentParkinson’s disease

Identifiers

PMID36845659
PMCPMC9950580

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.