Evidence map›Paper›PMID 36845636›Full record

ArticleBioMed research international2023

Whole Exome Sequence Analysis for Inborn Errors of IL-12/IFN-

Faaiz Ul Hassan, Mohammed M Aljeldah, Fozia Fozia, Mubbashir Hussain, Taj Ali Khan, Sami Siraj, Ijaz Ahmad, Muhammad Qasim, Imran Khan, John P Giesy and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Faaiz Ul HassanDepartment of Microbiology, Kohat University of Science and Technology, KP, Kohat 26000, Pakistan.
Mohammed M AljeldahDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.ORCID https://orcid.org/0000-0001-5335-2809
Fozia FoziaDepartment of Biochemistry, KMU Institute of Medical Sciences, Kohat, KP 26000, Pakistan.
Mubbashir HussainDepartment of Microbiology, Kohat University of Science and Technology, KP, Kohat 26000, Pakistan.ORCID https://orcid.org/0000-0002-9828-0615
Taj Ali KhanInstitute of Pathology and Diagnostic Medicine, Khyber Medical University Peshawar, KP 25000, Pakistan.
Sami SirajInstitute of Pharmaceutical sciences, Khyber Medical University Peshawar, KP 25000, Pakistan.ORCID https://orcid.org/0000-0002-4595-0232
Ijaz AhmadDepartment of Chemistry, Kohat University of Science and Technology, KP, Kohat 26000, Pakistan.ORCID https://orcid.org/0000-0002-9139-1611
Muhammad QasimDepartment of Microbiology, Kohat University of Science and Technology, KP, Kohat 26000, Pakistan.
Imran KhanInstitute of Pharmaceutical sciences, Khyber Medical University Peshawar, KP 25000, Pakistan.
John P GiesyToxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada S7N 5B3.ORCID https://orcid.org/0000-0003-1931-9962
Mourad A M Aboul-SoudChair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.ORCID https://orcid.org/0000-0001-9395-0563
Khyber Medical University · PKKohat University of Science and Technology · PKBaylor University · USKing Saud University · SAUniversity of Hafr Al-Batin · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The IL-12/IFN- Objective: The study is aimed at using whole exome sequencing (WES) to screen out genetic defects in IL-12/IFN- Methods: WES using next-generation sequencing was performed on a single patient diagnosed with recurrent typhoid fever. Following alignment and variant calling, exomes were screened for mutations in 25 genes that are involved in the IL-12/IFN- Results: Out of 25 possible variations in the IL-12/IFN- Conclusion: Applying WES to the patient with recurrent typhoid fever detects variants that are not much important as other genes in the IL-12/IFN-

Indexed as

Typhoid FeverExomeHumansInterferon-gammaInterleukin-12MutationRecurrenceSequence AnalysisIFNG protein, humanInterferon-gammaInterleukin-12

Identifiers

PMID36845636
PMCPMC9957627
OpenAlexW4321185067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.