ArticleFrontiers in neuroscience2023
A robust role for motor cortex.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Differences related to sex in adolescent obese Zucker rats: locomotor activity and dendritic arborization of neurons in layer V of the primary motor cortex.Histochemistry and cell biology · 2026Article
- Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.EBioMedicine · 2026Article
- Dynamic engagement of the motor cortex in controlling movement.bioRxiv : the preprint server for biology · 2026Article
- Distinct hindlimb motor cortex subregions encode forward and backward hindlimb movements in rats.Frontiers in systems neuroscience · 2026Article
- Complementary cortical and striatal encoding of locomotor preparation and performance.iScience · 2025Article
- Mapping neural subspace dynamics onto the structure of the mouse descending motor system.bioRxiv : the preprint server for biology · 2025Article
- Regional specialization of movement encoding across the primate sensorimotor cortex.Nature communications · 2025Article
- Physical activity and anodal-transcranial direct current stimulation: a synergistic approach to boost motor cortex plasticity.Brain communications · 2025Article
- The evolution of human-type consciousness - a by-product of mammalian innovation mechanism - a preliminary hypothesis.Frontiers in psychology · 2025Article
- The role of motor cortex in motor sequence execution depends on demands for flexibility.Nature neuroscience · 2024Article
- Learning and Control in Motor Cortex across Cell Types and Scales.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state.Nature communications · 2024Article
- Temporal scaling of motor cortical dynamics reveals hierarchical control of vocal production.Nature neuroscience · 2024Article
- Low- and high-level coordination of orofacial motor actions.Current opinion in neurobiology · 2023Review
- Neural dynamics in the rodent motor cortex enables flexible control of vocal timing.bioRxiv : the preprint server for biology · 2023Article
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- Unsupervised discovery of behaviorally relevant brain states in rats playing hide-and-seek.Current biology : CB · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
The role of motor cortex in non-primate mammals remains unclear. More than a century of stimulation, anatomical and electrophysiological studies has implicated neural activity in this region with all kinds of movement. However, following the removal of motor cortex, rats retain most of their adaptive behaviors, including previously learned skilled movements. Here we revisit these two conflicting views of motor cortex and present a new behavior assay, challenging animals to respond to unexpected situations while navigating a dynamic obstacle course. Surprisingly, rats with motor cortical lesions show clear impairments facing an unexpected collapse of the obstacles, while showing no impairment with repeated trials in many motor and cognitive metrics of performance. We propose a new role for motor cortex: extending the robustness of sub-cortical movement systems, specifically to unexpected situations demanding rapid motor responses adapted to environmental context. The implications of this idea for current and future research are discussed.
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