Evidence map›Paper›PMID 36845109›Full record

ArticleFrontiers in immunology2023

Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon.

Sheng Song, Dezhen Tu, Chengbo Meng, Jie Liu, Belinda Wilson, Qingshan Wang, Yen-Yu Ian Shih, Hui-Ming Gao, Jau-Shyong Hong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sheng SongNeuropharmacology Section, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
Dezhen TuNeuropharmacology Section, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
Chengbo MengIn Vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
Jie LiuNeuropharmacology Section, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
Belinda WilsonNeuropharmacology Section, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
Qingshan WangNational-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, China.
Yen-Yu Ian ShihBiomedical Research Imaging Center, University of North Caroline at Chapel Hill, Chapel Hill, NC, United States.
Hui-Ming GaoMinistry of Education (MOE) Key Laboratory of Model Animal for Disease Study, Institute for Brain Sciences, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, School of medicine, Nanjing University, Nanjing, China.
Jau-Shyong HongNeuropharmacology Section, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, United States.
National Institute of Environmental Health Sciences · USUniversity of North Carolina at Chapel Hill · USDalian Medical University · CNNanjing University · CN

Funding

UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Circuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3M
Mechanisms underlying positive and negative BOLD in the striatumRF1MH117053 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2018 to 2019
$4.0M
ROLES OF BRAIN NEUROIMMUNE SYSTEM IN NEURODEGENERATIONZ01ES090082 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HONG, JAU-SHYONG SHYONG · 1997 to 2008
$3.9M
Chemogenetic Dissection of Neuronal and Astrocytic Compartment of the BOLD SignalR01MH111429 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2016 to 2020
$2.7M
9.4T Small Animal MRI scanner at UNCS10OD026796 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$2.0M
AVANCE NEO upgrade for the BioSpec 9.4T/30cm MRI system at UNCS10MH124745 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHIH, YEN-YU IAN · 2020 to 2020
$600k
Intramural NIH HHS Z01 ES090082NIAAA NIH HHS P60 AA011605NICHD NIH HHS P50 HD103573NIH HHS S10 OD026796NIMH NIH HHS R01 MH111429NIMH NIH HHS R01 MH126518NIMH NIH HHS RF1 MH117053NIMH NIH HHS S10 MH124745
6 · The paper itself

Abstract

Clinical and pathological evidence revealed that α-synuclein (α-syn) pathology seen in PD patients starts in the gut and spreads

Indexed as

SynucleinopathiesAnimalsBenzylaminesColonHumansInflammationMiceNorepinephrineBenzylaminesDSP 4Norepinephrinegut-brain axisinflammationnoradrenergic systemParkinson’s diseaseα-synuclein

Identifiers

PMID36845109
PMCPMC9950510
OpenAlexW4319984865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.