Evidence map›Paper›PMID 36845097›Full record

ArticleFrontiers in immunology2023

Characteristics of refined lymphocyte subsets changes in people living with HIV/AIDS during antiretroviral therapy period: An observation from Wuhan, China.

Rui Yuan, Ling Li, Wenjia Hu, Ke Zhuang, Ejuan Zhang, Yajun Yan, Ling Feng, Xiaoping Chen, Qian Cao, Hengning Ke and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rui YuanDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ling LiDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wenjia HuDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ke ZhuangAnimal Biosafety Shelter Laboratory (ABSL)-III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei, China.
Ejuan ZhangMedical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yajun YanDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ling FengDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Xiaoping ChenDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Qian CaoDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Hengning KeDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Xien GuiDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Rongrong YangDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wuhan University · CNZhongnan Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To analyze the changing characteristics of continuous monitoring of refined lymphocyte subsets in people living with HIV/AIDS (PLWHA) during ART period. Methods: Refined lymphocyte subsets was continuously monitored using flow cytometry for 173 PLWHA, who were hospitalized in Zhongnan Hospital of Wuhan University from August 17, 2021 to September 14, 2022. The effect of ART status and duration of ART on changes of refined lymphocyte subsets were compared in different groups. Then, the levels of refined lymphocyte subsets in PLWHA treated for more than 10 years were compared to those of 1086 healthy individuals. Results: In addition to conventional CD4 Conclusion: Persistent ART can gradually improve the immune status of PLWHA, which is manifested in the increase of lymphocytes, function recovery of lymphocytes and reduction of aberrant activation status of the immune system. After 10 years of standardized ART, most lymphocytes could return to levels of healthy persons, although it may take longer to complete recovery for CD4

Indexed as

CD28 AntigensHIV InfectionsHLA-DR AntigensHumansLeukocyte Common AntigensLymphocyte CountLymphocyte SubsetsT-LymphocytesCD28 AntigensHLA-DR AntigensLeukocyte Common Antigensantiretroviral therapyCD28HLA-DRPLWHArefined lymphocyte subsets

Identifiers

PMID36845097
PMCPMC9948076
OpenAlexW4319744521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.