Evidence map›Paper›PMID 36845082›Full record

ArticleFrontiers in immunology2023

Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.

Tracy X Cui, Alexander E Brady, Ying-Jian Zhang, Christina T Fulton, Adam M Goldsmith, Antonia P Popova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tracy X CuiDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Alexander E BradyDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Ying-Jian ZhangDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Christina T FultonDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Adam M GoldsmithDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Antonia P PopovaDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
University of Michigan · US

Funding

Early life hyperoxic exposure, lung innate immune responses, bronchopulmonary dysplasia and asthmaR01HL140572 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POPOVA, ANTONIA PETROVA · 2018 to 2022
$1.9M
NHLBI NIH HHS R01 HL140572
6 · The paper itself

Abstract

Premature infants with chronic lung disease, bronchopulmonary dysplasia (BPD), develop recurrent cough and wheezing following respiratory viral infections. The mechanisms driving the chronic respiratory symptoms are ill-defined. We have shown that hyperoxic exposure of neonatal mice (a model of BPD) increases the activated lung CD103+ dendritic cells (DCs) and these DCs are required for exaggerated proinflammatory responses to rhinovirus (RV) infection. Since CD103+ DC are essential for specific antiviral responses and their development depends on the growth factor Flt3L, we hypothesized that early-life hyperoxia stimulates Flt3L expression leading to expansion and activation of lung CD103

Indexed as

Bronchopulmonary DysplasiaHyperoxiaAnimalsDendritic CellsHumansInfant, NewbornInfant, PrematureLungMembrane ProteinsMiceflt3 ligand proteinMembrane Proteinsbronchopulmonary dysplasia (BPD)dendritic cellsFlt3Lhyperoxiaprematurity

Identifiers

PMID36845082
PMCPMC9950736
OpenAlexW4319985158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.