Evidence map›Paper›PMID 36844899›Full record

ArticleJournal of oral microbiology2023

Subgingival microbiome at different levels of cognition.

Nele Fogelholm, Jaakko Leskelä, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkälä, Maria Eriksdotter and 3 more

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Oral Microbiome Changes During Hospitalization in Older Adults Not Receiving Mechanical Ventilation.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025
    Observational
  7. Article
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nele FogelholmDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Jaakko LeskeläDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-9670-339X
Muhammed ManzoorDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-7939-1563
Jacob HolmerDivision of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.ORCID https://orcid.org/0000-0002-9627-2574
Susanna PajuDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-2048-3420
Kaija HiltunenDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-3307-6605
Hanna-Maria RoittoDepartment of Neurosciences, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-5466-2873
Riitta Kt SaarelaDepartment of Social Services and Health Care, Oral Health Care, Helsinki, Finland.ORCID https://orcid.org/0000-0002-1850-1757
Kaisu PitkäläDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-9659-6985
Maria EriksdotterDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.ORCID https://orcid.org/0000-0003-2498-4000
Kåre BuhlinDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Pirkko J PussinenDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-3563-1876
Päivi MäntyläSchool of Medicine, Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0003-2091-972X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts. Memory and Periodontitis (MINOPAR) include 202 home-living participants (50-80 years) in Sweden. Finnish Oral Health Studies in Older Adults (FINORAL) include 174 participants (≥65 years) living in long-term care in Finland. We performed oral examination and assessed the cognitive level with Mini Mental State Examination (MMSE). We sequenced the 16S-rRNA gene (V3-V4 regions) to analyse the subgingival bacterial compositions. The microbial diversities only tended to differ between the MMSE categories, and the strongest determinants were increased probing pocket depth (PPD) and presence of caries. However, abundances of 101 taxa were associated with the MMSE score. After adjusting for age, sex, medications, PPD, and caries, only eight taxa retained the significance in the meta-analyses of the two cohorts. Especially

Indexed as

cognitioncognitive declinemini mental state examination (MMSE)older adultsOral healthsubgingival microbiome

Identifiers

PMID36844899
PMCPMC9946326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.